Transient Ischemic Attack (TIA) and Spoken Language

NCT07206433 | Not Yet Recruiting

• 1 other identifier: TIASPEECHPROTOCOL3132025
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Transient Ischaemic Attack (also known as TIA or 'mini-stroke') affects about 46,000 people in the UK each year. It is assumed that people recover fully within 24 hours. However, subtle problems with speaking, and confidence with their communication skills can be long-term. This project will be the first in depth exploration of speaking abilities after recent TIA where there seemed to be a full recovery. The researchers will look for 90 volunteers for detailed testing. Thirty people who have had a TIA for the first time. For comparisons, the researchers will also include 60 volunteers without TIA (30 treated to prevent TIA and stroke; 30 who do not receive prevention treatments). Aims and methods:

1. 1.To find out if TIA makes speaking difficult.
2. 2.To find out if people are concerned about their speech and other thinking skills after TIA.
3. 3.To find out if speaking abilities and people's own views of their communication change over time (about three months after the TIA).

Conditions

TIA (Transient Ischemic Attack)

Keywords

TIA; Transient Ischemic Attack; speech; language

Outcome Measures

Primary Outcomes (5)

• Speech rate

  measured as number of words per minute

  From enrollment

• Mean length of sentence

  measured in number of words

  From enrollment

• Sentence complexity

  measured as number of complex sentences

  From enrollment

• Functional Memory Questionnaire

  Patient-reported measure of perceptions of memory, attention, language abilities; score range 0 to 140; higher scores mean a worse outcome

  From enrollment

• Communication Confidence Rating Scale for Aphasia

  Patient-reported measure of confidence of communication abilities; score range 0 to 600; higher scores mean worse outcome

  From enrollment

Secondary Outcomes (3)

• Filled pause rate

  From enrollment

• Lexical richness

  From enrollment

• Propositional idea density

  From enrollment

Eligibility Criteria

• Age: 40 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

TIA group: Individuals who have had a recent single medically confirmed TIA following an in-person review at a TIA clinic. Vascular risk factor group: People aged 40-75 with vascular risk factors (e.g., hypertension, diabetes, hyperlipidemia) who receive medical treatment for these conditions and have attended a TIA clinic but were not diagnosed with a TIA. Healthy group: People aged 40-75 who have no self-reported vascular risk factors for which they take medication.

You may not qualify if:

• Younger than 40 years or older than 85 years of age.
• English as a secondary language.
• Neurological conditions affecting cognitive function (e.g., Parkinson's disease, dementia, stroke).
• Self-reported, pre-existing speech or cognitive problems, developmental or acquired.
• Demonstrate noticeable difficulties carrying out project-related tasks.

Sponsors & Collaborators

• Newcastle University: lead
• Northumbria Healthcare NHS Foundation Trust: collaborator

Study Sites (1)

Newcastle University

Newcastle upon Tyne, Tyne and Wear, NE1 7RU, United Kingdom

Location

MeSH Terms

Conditions

Ischemic Attack, Transient; Speech; Language

Condition Hierarchy (Ancestors)

Brain Ischemia; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Verbal Behavior; Communication; Behavior

Study Officials

• Christos Salis, PhD

  Newcastle University

  PRINCIPAL INVESTIGATOR

• Lisa Shaw, MD

  Newcastle University

  STUDY CHAIR

• Christopher Price, MD

  Newcastle University

  STUDY CHAIR

• Mahmoud Kargar, MSc

  Newcastle University

  STUDY CHAIR

Central Study Contacts

Christos Salis, PhD

CONTACT

+441912088875; christos.salis@ncl.ac.uk

Janet Webster, PhD

CONTACT

+441912085235; janet.webster@ncl.ac.uk

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 23, 2025
• First Posted: October 3, 2025
• Study Start: October 1, 2025
• Primary Completion (Estimated): June 30, 2027
• Study Completion (Estimated): June 30, 2027
• Last Updated: October 3, 2025

Record last verified: 2025-04

Locations

GB (1)