Multimorbidity and Cardiovascular Risk Factors After Renal Transplant

NCT07205692 | Recruiting

• 1 other identifier: UHDB/2025/044
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Who can participate? Any adults over the age of 18 who have received a kidney transplant at the research centre are eligible for recruitment within the first month after transplant What does the study involve? The study involves observing and gathering data to understand how the health of people who receive a kidney transplant changes over the first year. In particular the investigators are interested in the risk factors for heart disease and stroke, and how these change over the first year of transplant. The investigators are also interested in multiple health conditions, and how these impact patients after transplant. There are no interventions but there will be measurements of diagnoses, risk factors for heart disease and stroke, and assessments of physical fitness Blood pressure, BMI, routine blood tests as well as assessing muscle and fat changes, how fit patients are and what new health conditions they have. What are the possible benefits and risks of participating? There is no active treatment or intervention, so there are no risks of benefits compared to normal care. Where is the study run from? University Hospitals of Derby and Burton NHS trust, at the Royal Derby hospital Renal Department. When is the study starting and how long is it expected to run for? The study is expected to start 1/9/2025 and run for 2 years. Who is funding the study? The only costs of the study are funding for the staff member running the study, who is funded by the NIHR as an academic research fellow Who is the main contact? Dr Samuel Strain, Samuel.strain@nottingham.ac.uk

Conditions

Kidney Transplant; Cardiovascular (CV) Risk; Multimorbidity

Keywords

multimorbidity; kidney transplant; renal transplant; cardiovascular risk

Outcome Measures

Primary Outcomes (1)

• Multimorbidity

  The changes from baseline to year one of multimorbidity in the one year post kidney transplantation as measured by a disease count.

  One year after transplant

Secondary Outcomes (8)

• Blood pressure

  One year

• Lipid levels

  One year

• Weight

  One year

• HbA1c

  One year

• Qualitative interview

  One year after transplant

Study Arms (1)

Incident kidney transplants

Incident kidney transplants returning from surgical centre for follow up

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Incident kidney transplant recipients returning to referring centre

You may qualify if:

• Age ≥ 18 years old
• Capable of giving informed consent
• In receipt of a single organ renal transplant and being followed up by UHDB as the referring team.

You may not qualify if:

• Graft failure before return to follow up

Sponsors & Collaborators

• University Hospitals of Derby and Burton NHS Foundation Trust: lead

Study Sites (1)

Royal Derby Hospital

Derby, Derbyshire, DE22 3NE, United Kingdom

RECRUITING

Study Officials

• Nicholas Selby

  University of Nottingham and UHDB

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Samuel Strain, BMBS

CONTACT

+44 1283 566 333; samuel.strain@nhs.net

Nicholas Selby

CONTACT

nick.selby@nhs.net

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 10, 2025
• First Posted: October 3, 2025
• Study Start: September 5, 2025
• Primary Completion (Estimated): August 1, 2027
• Study Completion (Estimated): August 1, 2027
• Last Updated: October 3, 2025

Record last verified: 2025-09

Locations

GB (1)