Serum Electrolyte Abnormalities as Prognostic Factor for Outcome in Critically Ill Children

NCT07205562 | Not Yet Recruiting

• 1 other identifier: Serum Electrolyte Disorders
• Study Type: observational
• Target: 200
• Locations: 0 countries
• Sites: N/A

Brief Summary

The aim of this study is to evaluate the clinical profile and outcome of children with serum electrolyte abnormalities admitted at Pediatric Intensive Care Unit in Assuit University Children Hospital.

Conditions

Electrolytes Abnormalities; Children; Prognostic Factors

Outcome Measures

Primary Outcomes (1)

• Incidence and Correlation of Electrolyte Abnormalities With PICU Mortality

  To determine the frequency and distribution of electrolyte abnormalities (sodium, potassium, calcium, magnesium, phosphate, and chloride) in critically ill children admitted to the PICU, and to evaluate their correlation with PICU mortality.

  average of hospital stay: up to 28 days

Secondary Outcomes (1)

• Risk Factors and Clinical Outcomes Correlated With Electrolyte Abnormalities in PICU Patients

  average hospital stay: up to 28 days

Eligibility Criteria

• Age: 1 Month - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

The study population will include critically ill children admitted to the Pediatric Intensive Care Unit (PICU) at Assiut University Children's Hospital who are found to have serum electrolyte abnormalities during their admission. Patients will be enrolled consecutively over the study period, regardless of gender, aged from 1 month to 18 years.

You may qualify if:

• Children aged 1 month to 18 years.
• Admission to the PICU for any acute medical or surgical reason.
• Availability of serum electrolyte data within the first 24 hours of admission

You may not qualify if:

• Children with known chronic kidney disease and chronic liver disease
• Patients with incomplete medical records or missing electrolyte data.
• Children discharged or deceased within 6 hours of admission.
• Patients with chronic liver diseases, or previously diagnosed with adrenal gland disorders

Sponsors & Collaborators

• Assiut University: lead

Related Publications (4)

• Raza M, Kumar S, Ejaz M, Azim D, Azizullah S, Hussain A. Electrolyte Imbalance in Children With Severe Acute Malnutrition at a Tertiary Care Hospital in Pakistan: A Cross-Sectional Study. Cureus. 2020 Sep 19;12(9):e10541. doi: 10.7759/cureus.10541.

  PMID: 33094080 BACKGROUND

• Rewers A, Kuppermann N, Stoner MJ, Garro A, Bennett JE, Quayle KS, Schunk JE, Myers SR, McManemy JK, Nigrovic LE, Trainor JL, Tzimenatos L, Kwok MY, Brown KM, Olsen CS, Casper TC, Ghetti S, Glaser NS; Pediatric Emergency Care Applied Research Network (PECARN) FLUID Study Group. Effects of Fluid Rehydration Strategy on Correction of Acidosis and Electrolyte Abnormalities in Children With Diabetic Ketoacidosis. Diabetes Care. 2021 Sep;44(9):2061-2068. doi: 10.2337/dc20-3113. Epub 2021 Jun 29.

  PMID: 34187840 BACKGROUND

• Zieg J, Ghose S, Raina R. Electrolyte disorders related emergencies in children. BMC Nephrol. 2024 Aug 30;25(1):282. doi: 10.1186/s12882-024-03725-5.

  PMID: 39215244 BACKGROUND

• Subba Rao SD, Thomas B. Electrolyte abnormalities in children admitted to pediatric intensive care unit. Indian Pediatr. 2000 Dec;37(12):1348-53. No abstract available.

  PMID: 11119337 BACKGROUND

Central Study Contacts

Menna Allah Ahmed Hussein, Principal Investigator

CONTACT

+201092583368; Menna.17289766@med.aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: September 17, 2025
• First Posted: October 3, 2025
• Study Start: October 1, 2025
• Primary Completion (Estimated): October 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: October 3, 2025

Record last verified: 2025-09