Prevalence of Inappropriate Prescriptions and Omitted Therapies in Hospitalized Elderly: STOPP/START Criteria Analysis

NCT07202962 | Completed

• 1 other identifier: 1239
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Evaluate the prevalence of potentially inappropriate prescriptions (PIPs) and potential omitted prescriptions (PPOs) in elderly patient upon admission to the acute geriatric department, based on adherence or non-adherence to the recommendations specified in STOPP and START criteria.

Conditions

Polypharmacy (People Under Treatment With 5 or More Drugs); Elderly (People Aged 65 or More); Deprescribing; Hospitalization

Keywords

polypharmacotherapy; interactions; elderly people; STOPP&START CRITERIES; DEPRESCRIBING

Outcome Measures

Primary Outcomes (2)

• Prevalence of Potentially Inappropriate Prescriptions (PIP) (%)

  Percentage of elderly patients with at least one potentially inappropriate prescription identified at hospital admission (day 0) and at discharge (day 1) in the acute geriatric ward, based on the STOPP criteria. The measurement is performed by comparing the patient's medication regimen with the recommendations provided in the STOPP criteria.

  Data collected at time Day 0 is analyzed by day 4. Data collected at time Day 1 is analyzed by day 4

• Prevalence of Potentially Omitted Prescriptions (PPO) (%)

  Percentage of elderly patients with at least one potentially omitted prescription identified at hospital admission (day 0) and at discharge (day 1) in the acute geriatric ward, based on the START criteria. The measurement is based on the absence of indicated medications according to the START criteria recommendations.

  Data collected at time Day 0 is analyzed by day 4. Data collected at time Day 1 is analyzed by day 4

Secondary Outcomes (3)

• Prevalence of Pharmacological Interactions (%)

  Data collected at time Day 0 is analyzed by day 4. Data collected at time Day 1 is analyzed by day 4

• Post-Discharge Destination (Binary Variable)

  Data collected at time Day 0 is analyzed by day 4.

• Presence of Geriatric Syndromes (Yes/No)

  Data collected at time Day 0 is analyzed by day 4.

Interventions

medication review and deprescribing DRUG

The study protocol includes the following assessments: * T0: first data collection upon admission to the ward; * T1 assessment: pharmacological review at discharge. Subjects who meet all study eligibility criteria will come consecutively enrolled in the study during admission to the department (T0). By consulting the electronic health record, interviewing patients and family members and personal documentation, the following data will be collected: * Remote and immediate pathological history; * Family and social history; * Home therapy; * BRIEF-MPI. Home therapy and therapy suggested at discharge will be compared with the STOPPandSTART criteria to evaluate the prevalence of potential therapies inappropriate and to study possible interactions and contraindications pharmacological and for reporting possible adverse reactions to drugs. The prevalence and possible prevalence of each individual STOPPandSTART criterion will be assessed association with other variables of interest.

Eligibility Criteria

• Age: 75 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Elderly patients aged over 75 years on polypharmacotherapy, hospitalized for acute conditions in the Geriatrics Department of AULSS 7 Pedemontana Hospital.

You may qualify if:

• Elderly patients (aged \>75 years) admitted to the Geriatrics Department at Santorso, Alto Vicentino Hospital.
• Currently undergoing pharmacological treatment at the time of admission.

You may not qualify if:

• Patients placed in palliative therapy upon admission to the department due to incurability of the underlying pathologies

Sponsors & Collaborators

• Regione del Veneto - AULSS n. 7 Pedemontana: lead

Study Sites (1)

Regione del Veneto - AULSS n. 7 Pedemontana

Santorso, Vicenza, 36014, Italy

Location

MeSH Terms

Interventions

Medication Review; Deprescriptions

Intervention Hierarchy (Ancestors)

Medication Systems; Organization and Administration; Health Services Administration; Patient Care Management; Drug Therapy; Therapeutics

Study Officials

• Luca Pellizzari Dr. Pellizzari, DR

  Regione del Veneto - AULSS n. 7 Pedemontana

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of Geriatrics

Study Record Dates

• First Submitted: February 27, 2025
• First Posted: October 2, 2025
• Study Start: July 17, 2024
• Primary Completion: December 31, 2024
• Study Completion: December 31, 2024
• Last Updated: October 2, 2025

Record last verified: 2024-12

Locations

IT (1)