NCT07202689

Not Yet Recruiting

The Predictive Value of Multimodal Brain Monitoring for Peri...

Beijing Tiantan Hospital Source

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Other study identifiers

Sponsor study identifier

2025-09-10

Study Type

observational

Estimated enrollment

369

Locations

0 countries

Sites

N/A

Timeline

Study Start

October 1, 2025

Estimated (date passed)

This estimate has passed. The registry has not confirmed an actual date for this milestone.

Primary Completion

November 30, 2028

Estimated

Planned date reported by the registry; this milestone is not confirmed as achieved.

Study Completion

December 31, 2028

Estimated

Planned date reported by the registry; this milestone is not confirmed as achieved.

Brief Summary

Postoperative stroke following cardiac surgery is associated with a ninefold increase in mortality risk compared to patients without stroke. Perioperative monitoring in cardiac surgery involves a range of complex and diverse techniques, presenting significant challenges for anesthetic management. Multimodal brain monitoring technology offers a novel approach to cerebral protection during the perioperative period of cardiac surgery by integrating hemodynamic parameters, autonomic nervous responses, cerebral oxygen saturation and indices, electroencephalographic activity, and cerebral blood flow velocity. Therefore, this study aims to evaluate the comprehensive early-warning efficacy of multimodal brain monitoring for perioperative stroke in cardiac surgery patients, determine the cumulative incidence of perioperative stroke-including covert stroke-and provide a new theoretical basis for optimizing cerebral protection strategies in cardiac surgery.

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: not yet recruiting
Estimated enrollment: 369 participants
Study completion date: December 31, 2028
Estimated
Planned date reported by the registry; this milestone is not confirmed as achieved.
Listed locations: 0 countries · 0 sites

Trial Relationships

Click on a node to explore related trials.

Some registry-reported names shown below are not yet linked in this graph.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

First Submitted
September 24, 2025
Actual (reported)
Study Start
October 1, 2025
Estimated (date passed)
This estimate has passed. The registry has not confirmed an actual date for this milestone.
First Posted
October 2, 2025
Actual (reported)
Primary Completion
November 30, 2028
Estimated
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 31, 2028
Estimated
Planned date reported by the registry; this milestone is not confirmed as achieved.

Last Updated: October 2, 2025
Status Verified: September 2025
Last Update Submitted: September 24, 2025

Conditions

Covert Stroke Multimodal Monitoring Perioperative Stroke

Outcome Measures

Primary Outcomes (1)

The incidence of perioperative stroke
Perioperative stroke is diagnosed by MRI
48 hours preoperatively and 3-7 days postoperatively

Study Arms (2)

With stroke

Device: Multimodal monitoring

Without stroke

Device: Multimodal monitoring

Interventions

Multimodal monitoringDevice

Multimodal monitoring technology offers a novel approach to cerebral protection during the perioperative period of cardiac surgery by integrating hemodynamic parameters, autonomic nervous responses, cerebral oxygen saturation and indices, electroencephalographic activity, and cerebral blood flow velocity.

With strokeWithout stroke

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years+

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodProbability Sample

Study Population

The population will be selected from patients who schedule to receive elective cardiac surgery in Beijing Tiantan Hospital.

You may qualify if:

Patients scheduled for elective cardiac surgery

Sponsors & Collaborators

Beijing Tiantan Hospital
Otherlead

Study Officials

Yuming Peng, MD,Ph.D
Beijing Tiantan Hospital
PRINCIPAL INVESTIGATOR

Central Study Contacts

Yuming Peng, MD,Ph.D

CONTACT

8610-59976658 florapym766@163.com

Study Design

Study Type: observational
Observational Model: COHORT
Time Perspective: PROSPECTIVE
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Deputy chief of Department of Anesthesiology

Study Record Dates

First Submitted

September 24, 2025

First Posted

October 2, 2025

Study Start

October 1, 2025

Estimated (date passed)

This estimate has passed. The registry has not confirmed an actual date for this milestone.

Primary Completion

November 30, 2028

NCT01369537

Neurological Impact of Vascular Events In Noncardiac Surgery patIents cOhort evaluatioN Pilot Study

Completed

NCT01758952

Incidence and Risk Factors of Peri-operative Stroke in Non-cardiac,Non-neurosurgical Surgeries

Unknown

Presence of at least one of the following high-risk factors for stroke: a.Peripheral vascular disease (history of peripheral artery bypass grafting, amputation for ischemia, Ankle-Brachial Pressure Index \< 0.9, or history of abdominal aortic aneurysm repair).b.Cerebrovascular disease (history of stroke, transient ischemic attack, or carotid stenosis \>70%).c.Renal insufficiency (Glomerular Filtration Rate \< 60 mL/min/1.73m²).d.Diabetes mellitus (requiring oral hypoglycemic agents and/or insulin therapy).e.Urgent coronary artery bypass grafting (inpatient requiring revascularization due to acute coronary syndrome or myocardial infarction).f.Recent smoking history (within 1 year).g.Left ventricular ejection fraction \< 35%

Provision of signed informed consent

You may not qualify if:

Contraindication to magnetic resonance imaging (e.g., claustrophobia, inability to lie flat for the duration of the study, presence of a pacemaker or implantable cardioverter-defibrillator, or other metallic implants)
Inability to complete cognitive function assessments
Patients with psychiatric, legal disabilities or under legal guardianship
Life expectancy of less than 3 months
Women who are lactating or pregnant
Diagnosis of any type of dementia

Contact the study team to confirm eligibility.

Estimated

Planned date reported by the registry; this milestone is not confirmed as achieved.

Study Completion

December 31, 2028

Estimated

Planned date reported by the registry; this milestone is not confirmed as achieved.

Last Updated

October 2, 2025

Record last verified: 2025-09

Data Sharing

IPD Sharing: Will not share

Source record

Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.

Source: ClinicalTrials.gov.

JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.

Registry identifier: NCT07202689
Data provider: ClinicalTrials.gov
Source updated: 2025-10-02
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:39:56 UTC

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

Study Start

First Posted

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Study Arms (2)

With stroke

Without stroke

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record