Transversalis Fascia Plane Block Versus Intrathecal Morphine for Postoperative Analgesia in Total Abdominal Hysterectomy

NCT07201272 | Completed

• 1 other identifier: 36264PR1337/8/25
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare the ultrasound-guided transversalis fascia plane (TFP) block and intrathecal morphine for postoperative analgesia in patients undergoing total abdominal hysterectomy (TAH).

Conditions

Transversalis Fascia Plane Block; Intrathecal Morphine; Postoperative Analgesia; Total Abdominal Hysterectomy

Outcome Measures

Primary Outcomes (1)

• Time to the 1st rescue analgesia

  Time to the first request for the rescue analgesia (time from the end of surgery to first dose of morphine administrated).

  24 hours postoperatively

Secondary Outcomes (3)

• Total morphine consumption

  24 hours postoperatively

• Degree of pain

  24 hours postoperatively

• Incidence of adverse events

  24 hours postoperatively

Study Arms (2)

TFP group

EXPERIMENTAL

Patients will receive spinal anesthesia (using 3.5 mL of hyperbaric bupivacaine 0.5%) with bilateral transversalis fascia plane (TFP) block (using 20 mL of bupivacaine 0.25%) at the end of surgery.

Other: Transversalis fascia plane block

IM group

EXPERIMENTAL

Patients will receive spinal anesthesia (using 3 mL of hyperbaric bupivacaine 0.5%) + (75 µg morphine diluted in 0.5ml saline) with sham block at the end of surgery.

Drug: Morphine

Interventions

Morphine DRUG

Patients will receive spinal anesthesia (using 3 mL of hyperbaric bupivacaine 0.5%) + (75 µg morphine diluted in 0.5ml saline) with sham block at the end of surgery.

IM group

Transversalis fascia plane block OTHER

Patients will receive spinal anesthesia (using 3.5 mL of hyperbaric bupivacaine 0.5%) with bilateral transversalis fascia plane (TFP) block (using 20 mL of bupivacaine 0.25%) at the end of surgery.

TFP group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Gender Eligibility Details: Women Undergoing Total Abdominal Hysterectomy
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age from 18 to 65 years.
• American Society of Anesthesiology (ASA) physical status I-II.
• Women undergoing total abdominal hysterectomy (TAH) under spinal anesthesia.

You may not qualify if:

• History of allergies to local anesthetics.
• Local infection at the site of injection.
• Bleeding disorders.
• History of chronic use of analgesic.
• Physical or mental conditions.
• Hepatic, renal or cardiac disease.
• Contraindication to spinal anesthesia.

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

Tanta University

Tanta, 31527, Egypt

Location

MeSH Terms

Interventions

Morphine

Intervention Hierarchy (Ancestors)

Morphine Derivatives; Morphinans; Opiate Alkaloids; Alkaloids; Heterocyclic Compounds; Heterocyclic Compounds, Bridged-Ring; Heterocyclic Compounds, 4 or More Rings; Heterocyclic Compounds, Fused-Ring; Phenanthrenes; Polycyclic Aromatic Hydrocarbons; Polycyclic Compounds

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Anesthesiology, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.

Study Record Dates

• First Submitted: September 23, 2025
• First Posted: October 1, 2025
• Study Start: October 1, 2025
• Primary Completion: April 11, 2026
• Study Completion: April 11, 2026
• Last Updated: April 22, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)