Anti-Redness Clinical Study

NCT07200492 | Completed

• 1 other identifier: C23036010
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

This clinical study is a single-center, randomized, split-face, on-site controlled trial conducted at Shanghai China-Norm Quality Technical Service Co., Ltd. The primary objective is to evaluate the efficacy of Eucerin Ultrasensitive Repair Intensive Source Serum in providing instant and long-lasting (24-hour) soothing and repairing effects under induced redness conditions. The design involves recruiting 30 healthy Chinese female subjects aged 18-60 years, who meet stringent inclusion/exclusion criteria, including absence of skin conditions and no recent participation in similar studies. Redness is induced using 50% Glycolic Acid on the entire face and tape stripping on both forearms.

Conditions

Redness

Outcome Measures

Primary Outcomes (6)

• Skin Erythema Index via Mexameter® MX 18

  From Baseline to 24-hour after product repeat application

• Colorimetry (avalue) via Chromameter CM26dG *

  from Baseline to 24-hour after product repeat application

• Skin Scaliness (Desquamation) via Squamescan® 850A

  from Baseline to 24-hour after product repeat application

• Forearm Skin Redness (avalue) via Cross-Polarized Light Imaging *

  The a\*value is a parameter in the CIELAB color space (also known as Lab) that quantifies a color's position along the red-green axis .

  From Baseline to 24-hour after product repeat application

• Facial Skin Redness and Colorimetry (a* value) via VISIA-CRP Imaging

  from Baseline to 24-hour after product repeat application

• Skin Surface Evenness (SEsc) via UV Video Capture and SELS Analysis

  from Baseline to 24-hour after product repeat application

Study Arms (4)

Facial Test Arm

OTHER

Other: Facial serum application

Facial Control Arm

NO INTERVENTION

Arm Test Arm

OTHER

Other: Forearm serum application

Arm Control Arm

NO INTERVENTION

Interventions

Facial serum application OTHER

The trained technician will apply the 0.3g-0.4g investigational products on the subject's half face.

Facial Test Arm

Forearm serum application OTHER

The trained technician will apply the (2mg±0.1mg)/cm² investigational products on the subject's forearm.

Arm Test Arm

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Chinese female whose age range from 18 to 60 years old;
• Be in general good health and good mental state;
• Have no any broken,scars,birthmarks and other imperfections on the test area;
• Redness/erythema≥grade 2 after modelling inducing and the score of redness must be increased after inducing;
• Not currently be participating in any other study involving the test area(Face and Forearm);
• Not have participated in any other study involving the test area in the past one month;
• Be willing to read,understand and able to sign the Informed Consent Form and Photo Release From;
• Be willing to comply with all study protocol requirements.

You may not qualify if:

• Intending to get pregnant, be pregnant, be lactating, be within 6 months of delivery or be unwilling to take necessary precautions to avoid a pregnancy;
• Having used antihistamine drugs in the past 1 week or immunosuppressants in the past 1 month;
• Taken anti-allergic drug/injections in the past 1 month;
• Presently have allergies, allergic dermatitis or skin disease;
• Have sensitivity or even allergy to topical products, ingredients or fragranced products;
• Have history of allergies;
• Have history of suffering from skin diseases (such as psoriasis, eczema, skin cancer, etc.);
• Have used any anti-inflammatory treatment on the test area within 2 months prior to this study starting date;
• Has a chronic medical condition that may interfere with testing (e.g., asthma, insulin-dependent diabetes, lupus, rheumatoid arthritis or other immune/auto-immune diseases);
• Have used any scrubs or peeling product (regardless of method) or self-tanning products or oil control products in the past 3 days;
• Have received cosmetic medical procedures on the face (such as injectable anti-wrinkle products, cosmetic surgery, tattoo removal, home light facial procedures or home use medical devices, etc.) in the past 1 month;
• Have excessive sun exposure or ultraviolet light exposure in the past 1 month;
• Have applied ortho-hydroxybenzoic acid, hydroquinone in the past 3 months; or used prescriptions (such as antibiotic, retinoids, alpha hydroxyl acid and steroid), oral contraceptives；
• Avoid providing emergency contact;
• Subjects that are not compliant with the selection criteria or not proper for participation as determined by Principal Investigator;

Sponsors & Collaborators

• ChinaNorm: lead

Study Sites (1)

Shanghai China-norm Quality Technical Service Co., Ltd.

Shanghai, Shanghai Municipality, 200072, China

Location

MeSH Terms

Conditions

Erythema

Condition Hierarchy (Ancestors)

Skin Diseases; Skin and Connective Tissue Diseases; Skin Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 11, 2025
• First Posted: October 1, 2025
• Study Start: January 15, 2024
• Primary Completion: January 22, 2024
• Study Completion: January 24, 2024
• Last Updated: October 1, 2025

Record last verified: 2025-09

Locations

CN (1)