The Role of Ovarian PRP Therapy in Poseidon Poor Responders Women Undergoing ICSI Cycle

NCT07199868 | Completed DMC

• 2 other identifiers: 0009-0007-1354-0259non
• Study Type: interventional
• Target: 102
• Locations: 1 country
• Sites: 2

Brief Summary

Objective : This study aims to evaluate the impact of ovarian PRP therapy compared to control in Poseidon females undergoing ICSI cycles. Material and Methods: A randomized controlled trial was conducted from Jan 2024 to Feb 2025, involving 102 Poseidon women, Participants were divided into a PRP group (n=50), who received ovarian PRP injections and a control group (n=52), who received no PRP. All participants underwent ICSI cycles, embryological and pregnancy outcomes were compared between both groups within each Poseidon group.

Conditions

Poor Ovarian Reserve; Platelet Derived Growth Factor

Outcome Measures

Primary Outcomes (1)

• numbers of Meta phase II oocytes and embryos post ovarian PRP

  Primary embryological outcomes including; metaphase II oocytes and embryos numbers in addition to their quality post ovarian PRP were compared in both study \& control groups

  one year

Study Arms (1)

ovarian PRP injection in poor responders

EXPERIMENTAL

During early-mid follicular phase, using TV-US guidance and conscious sedation, 1.5 ml of PRP was injected into each ovary's subcortical layer using a 17-gauge ovum pick-up needle.

Procedure: During early-mid follicular phase, using TV-US guidance and conscious sedation, 1.5 ml of PRP was injected into each ovary's subcortical layer using a 17-gauge ovum pick-up needle.

Interventions

During early-mid follicular phase, using TV-US guidance and conscious sedation, 1.5 ml of PRP was injected into each ovary's subcortical layer using a 17-gauge ovum pick-up needle. PROCEDURE

During early-mid follicular phase, using TV-US guidance and conscious sedation, 1.5 ml of PRP was injected into each ovary's subcortical layer using a 17-gauge ovum pick-up needle.

ovarian PRP injection in poor responders

Eligibility Criteria

• Age: 21 Years - 49 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• infertile Poseidon groups 2, 3, 4 women 2- no history of chronic illness or pelvic pathology. 3- All male partners were either normozoospermic or had mild OAT delivered fresh ejaculated samples for ICSI.

You may not qualify if:

• ovarian failure due to sex chromosome abnormalities, 2- current use of anticoagulants 3- history of bleeding disorders.

Sponsors & Collaborators

• Karbala University: lead

Study Sites (2)

Collage of medicine

Baghdad, 00964, Iraq

Location

Collage of medicine

Karbala, 00964, Iraq

Location

MeSH Terms

Interventions

Conscious Sedation

Intervention Hierarchy (Ancestors)

Anesthesia and Analgesia

Study Officials

• Itlal J AL Asadi, MD

  Department of Obstetrics & Gynecology, College of Medicine, Karbala University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Masking Details: non
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: During early-mid follicular phase, using TV-US guidance and conscious sedation, 1.5 ml of PRP was injected into each ovary's subcortical layer using a 17-gauge ovum pick-up needle.

Study Record Dates

• First Submitted: September 9, 2025
• First Posted: September 30, 2025
• Study Start: January 1, 2024
• Primary Completion: February 28, 2025
• Study Completion: February 28, 2025
• Last Updated: September 30, 2025

Record last verified: 2025-09

Locations

IR (2)