Association Between Plasma D Dimer in Adult CAP and Severity of Inflammatory Response and Survival

NCT07199530 | Recruiting DMC

• 1 other identifier: FAMSU R 135/2025
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

This observational study aims to investigate the association between elevated plasma D-dimer levels and the inflammatory response, as well as its impact on survival in adult patients with community-acquired pneumonia. the study participants will be subjected to sampling for D-dimer and calculation of CURB-65 score. this aims to find the relation between them

Conditions

D-dimer

Outcome Measures

Primary Outcomes (1)

• find the correlation between plasma D-dimer level and the severity of CAP

  measuring D-dimer level (\< 500 µg/L consider negative) on admission and correlating this with CAP severity.

  in 6 months

Study Arms (1)

only one group which will include patients with CAP to take a blood sample for D-dimer

Other: Blood Product

Interventions

Blood Product OTHER

blood sample for D-dimer

only one group which will include patients with CAP to take a blood sample for D-dimer

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

the participant is those patients with CAP WHO will meet the inclusion criteria previously mentioned

You may qualify if:

• age ≥18 years
• diagnosis of CAP based on clinical symptoms, laboratory findings, and radiological evidence.

You may not qualify if:

• Patients with a history of coagulation disorders, cancer, or other chronic diseases, or refusal to participate.
• patients who have any clinical or radiological signs suggesting COVID-19 pneumonia.

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (1)

Ain Shams University hospitals

Cairo, Egypt

RECRUITING

Central Study Contacts

Hieba Gamal Ezzelregal

CONTACT

+201002041611; hiebagamal24@med.asu.edu.eg

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor

Study Record Dates

• First Submitted: September 22, 2025
• First Posted: September 30, 2025
• Study Start: March 23, 2025
• Primary Completion: March 1, 2026
• Study Completion: April 1, 2026
• Last Updated: February 24, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)