Molecular Research on Predictive Efficacy and New Therapeutic Targets for Nasopharyngeal Carcinoma

NCT07198802 | Not Yet Recruiting

• 1 other identifier: WuhanUH 1149-01
• Study Type: observational
• Target: 600
• Locations: 0 countries
• Sites: N/A

Brief Summary

To analyze the spatiotemporal dynamic evolution of nasopharyngeal carcinoma before and after immunotherapy and during tumor progression, 2\~3 key cell subsets or node molecules were screened to predict the curative effect. Spatial metabolome and organoids were used to elucidate the mechanism of key factors leading to immunotherapy tolerance in NPC and identify new targets for intervention.

Conditions

Nasopharyngeal Carcinoma (NPC)

Outcome Measures

Primary Outcomes (1)

• Failure-free survival (FFS)

  Failure-free survival is measured from day of diagnosis until treatment failure, death from any cause, or last follow-up visit, whichever occurred first

  3-year

Secondary Outcomes (1)

• Overall survival (OS)

  5-year

Study Arms (1)

Study Groups

Other: No Intervention

Interventions

No Intervention OTHER

This project involves no therapeutic intervention for the subjects.

Study Groups

Eligibility Criteria

• Age: 15 Years - 75 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with nasopharyngeal carcinoma who were admitted to our hospital

You may qualify if:

• Clearly diagnosed with nasopharyngeal carcinoma by pathology;
• Patients who have received combined radiotherapy, chemotherapy and immunotherapy in our hospital;
• Patients diagnosed in our hospital from January 2025 to December 2028;
• Have relatively complete clinical data;
• Age between 15 and 75 years old;

You may not qualify if:

• The final diagnosis of the participants is other diseases, including lymphoma, or oropharyngeal cancer, etc.;
• The participants failed to obtain pathological and imaging data for various reasons;
• Due to physical conditions, they did not undergo relevant examinations, refused to accept examinations, or interrupted treatment for other reasons, and were unable to complete clinical assessment.

Sponsors & Collaborators

• Union Hospital, Tongji Medical College, Huazhong University of Science and Technology: lead

MeSH Terms

Conditions

Nasopharyngeal Carcinoma

Condition Hierarchy (Ancestors)

Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Nasopharyngeal Neoplasms; Pharyngeal Neoplasms; Otorhinolaryngologic Neoplasms; Head and Neck Neoplasms; Neoplasms by Site; Nasopharyngeal Diseases; Pharyngeal Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 17, 2025
• First Posted: September 30, 2025
• Study Start: October 1, 2025
• Primary Completion (Estimated): December 1, 2028
• Study Completion (Estimated): December 1, 2028
• Last Updated: September 30, 2025

Record last verified: 2025-09