Association Between Blood Glucose Indicators and Heart Rate Variability in Non-diabetic Critically Ill Patients

NCT07198308 | Completed

• 1 other identifier: B2025-586
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Heart rate variability (HRV) is a simple way to check how well the body's automatic nervous system is working. It does this by looking at how the heart rate changes in the electrocardiogram. HRV can be divided into time domain and frequency domain. Time domain indicators assess the tone of the autonomic nerves. Frequency domain indicators reflect the regulation of the sympathetic and parasympathetic nerves. An imbalance of the body's nervous system can be reflected by HRV. Stress hyperglycemia (SIH) is when your blood glucose levels go up because of an acute disease. This is usually related to the body's stress response, but if your blood glucose levels go up too much, it can lead to complications. A high blood sugar level caused by stress is common in intensive care units. There is a strong link between this and the death rate and how long patients stay there. There are lots of nerve endings in the pancreas. Nerve fibres control the way islet α/β cells work to keep the right amount of glucose in the blood. We know that the pancreatic nerve is important for controlling blood glucose levels, but we don't fully understand how it does this.

Conditions

Hyperglycemia

Outcome Measures

Primary Outcomes (1)

• Correlation between glucagon and HRV in non-diabetic critically ill patients

  From enrollment to completion of indicator testing (within 24 hours)

Secondary Outcomes (1)

• The correlation between blood glucose and random insulin levels and HRV in non-diabetic critically ill patients

  From enrollment to completion of indicator testing (within 24 hours)

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients who were hospitalized in the Intensive Care Unit of Zhongshan Hospital Affiliated to Fudan University after the start of the study.

You may qualify if:

• Aged from 18 to 99 years old
• Informed consent has been signed

You may not qualify if:

• Under 18 years old
• Diagnosed with diabetes either prior to or during hospitalization
• Missing HRV values
• Missing blood glucose and random insulin values

Sponsors & Collaborators

• Shanghai Zhongshan Hospital: lead

Study Sites (1)

Zhongshan Hospital Fudan University

Shanghai, Shanghai Municipality, 200032, China

Location

MeSH Terms

Conditions

Hyperglycemia

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 22, 2025
• First Posted: September 30, 2025
• Study Start: October 1, 2025
• Primary Completion: December 31, 2025
• Study Completion: March 13, 2026
• Last Updated: March 17, 2026

Record last verified: 2026-03

Locations

CN (1)