Comparison Of Keratometric Readings Pre and Post Pterygium Excision With Conjunctival Autograft Transplantation

NCT07198126 | Enrolling By Invitation

• 1 other identifier: MughalETH1
• Study Type: interventional
• Target: 130
• Locations: 1 country
• Sites: 1

Brief Summary

Pterygium, often called "surfer's eye," is a common eye condition in which a raised, fleshy growth of tissue extends from the white part of the eye onto the clear cornea. This growth can cause redness, irritation, blurred vision, and, in advanced cases, changes in the curvature of the cornea leading to distorted vision (astigmatism). The condition is more frequent in people exposed to sunlight, dust, and dry environments. The standard treatment for symptomatic pterygium is surgical removal. However, simple removal has a high chance of recurrence. To reduce this risk, surgeons commonly use a technique called conjunctival autograft transplantation, where a small piece of the patient's own conjunctiva is placed over the area after excision. This method not only lowers the recurrence rate but may also improve vision by reducing corneal irregularities. This study is designed to measure the changes in corneal curvature (keratometric readings) before and after pterygium excision with conjunctival autograft transplantation. By comparing preoperative and postoperative measurements, the study aims to determine how much this surgery improves corneal shape and reduces astigmatism. The hypothesis is that pterygium excision with conjunctival autograft transplantation will lead to a significant improvement in keratometric readings and reduce irregular astigmatism, thereby improving visual quality. This research will provide local evidence of the effectiveness of this procedure and help guide treatment strategies for patients suffering from pterygium-related visual problems.

Conditions

Pterygium; Corneal Astigmatism

Keywords

Pterygium excision; Astigmatism correction; Conjunctival autograft transplantation; Refractive error

Outcome Measures

Primary Outcomes (1)

• Change in Keratometric Readings (K1 and K2)

  Keratometric readings, including the flat meridian (K1) and steep meridian (K2) of the anterior corneal surface, will be measured using a manual keratometer. The mean change in K-readings (measured in diopters) from baseline (pre-operative) to post-operative assessment will be calculated to evaluate corneal curvature improvement following pterygium excision with conjunctival autograft.

  Baseline (pre-operative) and 1 month post-operative.

Secondary Outcomes (1)

• Change in Astigmatism

  Baseline (pre-operative) and 1 month post-operative.

Study Arms (1)

Group Pterygium Excision with Conjunctival Autograft

EXPERIMENTAL

Patients will undergo surgical excision of pterygium followed by conjunctival autograft transplantation. The autograft will be harvested from the superior bulbar conjunctiva and secured at the excision site using sutures.

Procedure: Pterygium Excision with Conjunctival Autograft

Interventions

Pterygium Excision with Conjunctival Autograft PROCEDURE

Excision of primary Grade II or Grade III pterygium Conjunctival autograft harvested and transplanted at the excision site Graft secured with sutures

Group Pterygium Excision with Conjunctival Autograft

Eligibility Criteria

• Age: 30 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults of either sex aged \>30 to 70 years.
• Phakic eyes.
• Primary pterygium, Grade II or Grade III (as per protocol grading).
• Presence of corneal astigmatism on pre-operative assessment.
• Scheduled for pterygium excision with conjunctival autograft transplantation at the study site.
• Able to provide written informed consent and to attend the 1-month postoperative assessment.

You may not qualify if:

• Pseudophakic or aphakic eyes.
• Recurrent pterygium.
• Prior keratoplasty or trabeculectomy in the study eye.
• Keratoconus or other corneal pathologies that can independently induce astigmatism.
• Lenticular astigmatism or significant lens pathology affecting refraction.
• Eyes planned for simple pterygium excision without conjunctival autograft.
• Any ocular condition or systemic illness judged likely to interfere with keratometric or refractive measurements, follow-up, or surgical safety.

Sponsors & Collaborators

• Mughal Eye Trust Hospital: lead

Study Sites (1)

Mughal Eye Hospital Trust

Lahore, Punjab Province, 54000, Pakistan

Location

MeSH Terms

Conditions

Pterygium; Astigmatism; Refractive Errors

Condition Hierarchy (Ancestors)

Conjunctival Diseases; Eye Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: September 21, 2025
• First Posted: September 30, 2025
• Study Start: August 30, 2025
• Primary Completion: February 28, 2026
• Study Completion: February 28, 2026
• Last Updated: September 30, 2025

Record last verified: 2025-09

Locations

PA (1)