NCT07196319

Brief Summary

The goal of this study is to compare the proportion of compensatory hyperhidrosis patients after sympathectomy at T3 level and sympathectomy at T3-4 level. The main question it aims to answer is: can sympathectomyv at one level decrease the incidence of compensatory hyperhidrosis after primary hyperhidrosis.

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
46

participants targeted

Target at P25-P50 for all trials

Timeline
30mo left

Started Nov 2025

Typical duration for all trials

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress16%
Nov 2025Oct 2028

First Submitted

Initial submission to the registry

September 13, 2025

Completed
16 days until next milestone

First Posted

Study publicly available on registry

September 29, 2025

Completed
2 months until next milestone

Study Start

First participant enrolled

November 15, 2025

Completed
1.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 20, 2027

Expected
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

October 25, 2028

Last Updated

October 3, 2025

Status Verified

September 1, 2025

Enrollment Period

1.9 years

First QC Date

September 13, 2025

Last Update Submit

September 30, 2025

Conditions

Compensatory HyperhidrosisCompensatory Sweating

Keywords

compensatoryhyperhidrosissympathectomy

Outcome Measures

Primary Outcomes (1)

  • To compare the incidence of compensatory hyperhidrosis following T3 versus T3-4 sympathectomy.

    1 year post-sympathectomy

Secondary Outcomes (3)

  • severity of Compensatory hyperhidrosis by hyperhidrosis disease severity scale

    1 year post sympathectomy

  • recurrence rates of primary hyperhidrosis

    1 year post sympathectomy

  • site of compensatory hyperhidrosis

    1year post sympathectomy

Study Arms (2)

T3 sympathectomy

patients who underwent T3 sympathectomy for primary hyperhidrosis

T3-4 sympathectomy

patients who underwent through T3-4 sympathectomy for primary hyperhidrosis

Eligibility Criteria

Age6 Years+
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

population of study are patients with primary hyperhidrosis who are going through T3 or T3-4 sympathectomy.

You may qualify if:

  • Patients diagnosed with primary hyperhidrosis
  • Patients with palmar and\\or axillary hyperhidrosis.
  • Age ≥ 6 years

You may not qualify if:

  • History of Prior thoracic surgery.
  • History of prior disorder that cause hyperhidrosis ( obesity,autonomic neuropathy,menopause,gout,etc…)
  • History of prior systemic diseases cause hyperhidrosis (hyperthyroidism,DM,pheochromocytoma,Parkinson's disease,etc…)
  • Patients with psychological problems.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (7)

  • Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods. 2009 Nov;41(4):1149-60. doi: 10.3758/BRM.41.4.1149.

    PMID: 19897823BACKGROUND

  • Strutton DR, Kowalski JW, Glaser DA, Stang PE. US prevalence of hyperhidrosis and impact on individuals with axillary hyperhidrosis: results from a national survey. J Am Acad Dermatol. 2004 Aug;51(2):241-8. doi: 10.1016/j.jaad.2003.12.040.

    PMID: 15280843BACKGROUND

  • 4. Lin TS, et al. Clinical experience of thoracoscopic sympathetic block for primary hyperhidrosis: analysis of 3450 cases. J Thorac Cardiovasc Surg. 2001;121(3):566-74.

    BACKGROUND

  • 3. Hussein AF, et al. Unilevel (T3) versus Bilevel (T3 - T4) Sympathictomy in the Management of Palmar Hyperhidrosis: A Prospective Comparative Study. Clinics (Sao Paulo). 2024.

    BACKGROUND

  • 2. Liu X, Wang J, Liu Z, Sun X, Zheng J. Comparison of only T3 and T3-T4 sympathectomy for axillary hyperhidrosis: a retrospective study. J Thorac Dis. 2018;10(4):2095-101.

    BACKGROUND

  • Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007 May;39(2):175-91. doi: 10.3758/bf03193146.

    PMID: 17695343BACKGROUND

  • Licht PB, Pilegaard HK. Severity of compensatory sweating after thoracoscopic sympathectomy. Ann Thorac Surg. 2004 Aug;78(2):427-31. doi: 10.1016/j.athoracsur.2004.02.087.

    PMID: 15276490BACKGROUND

MeSH Terms

Conditions

Hyperhidrosis

Condition Hierarchy (Ancestors)

Sweat Gland DiseasesSkin DiseasesSkin and Connective Tissue Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
2 Years
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
principal investigator

Study Record Dates

First Submitted

September 13, 2025

First Posted

September 29, 2025

Study Start

November 15, 2025

Primary Completion (Estimated)

October 20, 2027

Study Completion (Estimated)

October 25, 2028

Last Updated

October 3, 2025

Record last verified: 2025-09