Effects of rTMS on Balance Performance and Functional Mobility in Parkinson's Disease

NCT07195773 | Completed

• 1 other identifier: CS2-23200
• Study Type: interventional
• Target: 21
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to investigate the effects of rTMS on balance performance and functional mobility in people with PD. Additionally, it further examines the effects of single-session low-frequency and high-frequency repetitive transcranial magnetic stimulation on balance performance and functional mobility.

Conditions

Motor Cortex; Excitability; Motor Skills Disorders; Parkinson Disease; Balance

Outcome Measures

Primary Outcomes (3)

• Dynamic balance

  Functional Reach Test

  FRT will be assessed before and immediately after each intervention. Each intervention is separated by a 2-week washout period. All assessments occur within an 4-week period.

• Functional mobility

  Timed Up and Go test

  TUG will be assessed before and immediately after each intervention. Each intervention is separated by a 2-week washout period. All assessments occur within an 4-week period.

• Motor function

  UPDRS-III

  UPDRS-III will be assessed before and immediately after each intervention. Each intervention is separated by a 2-week washout period. All assessments occur within an 4-week period.

Study Arms (3)

Group A

EXPERIMENTAL

Patients in this group first undergo high-frequency rTMS treatment, followed by a two-week rest period, then proceed to low-frequency rTMS after another two-week rest, and finally receive sham stimulation rTMS. rTMS high-frequency 1Hz 80%RMT rTMS low-frequency 1Hz 80%RMT rTMS sham 10HZ 20%RMT

Device: rTMS

Group B

EXPERIMENTAL

Patients in this group first undergo low-frequency rTMS treatment, followed by a two-week rest period, then proceed to high-frequency rTMS after another two-week rest, and finally receive sham stimulation rTMS. rTMS high-frequency 1Hz 80%RMT rTMS low-frequency 1Hz 80%RMT rTMS sham 10HZ 20%RMT

Device: rTMS

Group C

EXPERIMENTAL

Patients in this group first undergo sham stimulation rTMS treatment, followed by a two-week rest period, then proceed to high-frequency rTMS after another two-week rest, and finally receive low-frequency rTMS. rTMS high-frequency 1Hz 80%RMT rTMS low-frequency 1Hz 80%RMT rTMS sham 10HZ 20%RMT

Device: rTMS

Interventions

rTMS DEVICE

Participants will receive different stimulation approaches in sequences: high-frequency rTMS, low-frequency rTMS, and sham rTMS. They will be randomly assigned to three groups with different stimulation sequences. After each single stimulation, balance performance, functional mobility, and motor symptoms will be measured. In this study, eighteen PD patients with Hoehn and Yahr stage 1 to 3 will be recruited.

Group A; Group B; Group C

Eligibility Criteria

• Age: 40 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with primary Parkinson's disease
• Age: 40-85 years
• Hoehn and Yahr scale (H\&Y scale) : I-III
• Appropriate prescribed medication, and regular intake for more than 2 weeks
• Can walk more than 10m with or without the use of assistive devices

You may not qualify if:

• Any other neurological presentation (Excluding PD)
• Any neurological surgery that would affect participation in this experiment
• Orthopedic pathology and Cardiovascular issues
• MMSE≦24
• Exercise used for treatment in the last three months
• Contraindications for transcranial magnetic stimulation (Presence of metal implants in the head and neck, a pacemaker in the chest, personal or family history of epilepsy, recent brain injury, currently taking antidepressant medication.)

Sponsors & Collaborators

• Chung Shan Medical University: lead

Study Sites (1)

Chung Shan Medical Unirversity

Taichung, Southern District, 40201, Taiwan

Location

MeSH Terms

Conditions

Parkinson Disease; Motor Skills Disorders

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Neurodevelopmental Disorders; Mental Disorders

Study Officials

• LIU HSIN-HSUAN, PhD

  Assistant Professor

  STUDY CHAIR

• HONG SONG-PING, BSc

  student

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 7, 2024
• First Posted: September 29, 2025
• Study Start: December 16, 2024
• Primary Completion: November 19, 2025
• Study Completion: November 19, 2025
• Last Updated: February 27, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, CSR, ANALYTIC CODE
• Time Frame: 5 years

Locations

TW (1)