Association of Continuous Renal Replacement Therapy With Mortality and Length of Stay in Critically Burned Patients

NCT07195565 | Completed

• 1 other identifier: DrLutfiKirdarTRH-ANES-PTT-01
• Study Type: observational
• Target: 238
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective observational study aims to investigate the clinical outcomes of critically ill burn patients who underwent continuous renal replacement therapy (CRRT). Primary endpoints include the evaluation of RIFLE criteria, timing of CRRT initiation, and overall survival. Secondary endpoints consist of comorbidity status, requirement for mechanical ventilation, inotropic support, and hospital length of stay among non-survivors.

Conditions

Severe Burns; Acute Kidney Injury; Critical Illness

Keywords

Continuous Renal Replacement Therapy; RIFLE Criteria; Mortality; Hospital Length of Stay; Mechanical Ventilation; İnotropic Support

Outcome Measures

Primary Outcomes (3)

• RIFLE criteria classification at CRRT initiation

  Patients receiving CRRT will be classified according to the RIFLE criteria (Risk, Injury, Failure, Loss, End-stage kidney disease) at the time of CRRT initiation. The distribution across categories will be analyzed.

  Baseline( Day0, at CRRT initiation)

• Timing of CRRT initiation

  Date and time of initiation of continuous renal replacement therapy (CRRT), obtained from patient medical records.

  Baseline( Day0, at CRRT initiation, recorded from patient medical records)

• Survival status of patients

  Survival versus non-survival status at the end of hospitalization.

  At hospital discharge ( end of hospitalization)

Secondary Outcomes (4)

• Presence of comorbidities in non-survivors

  Baseline( Day0, at hospital admission)

• Requirement for mechanical ventilation in non-survivors

  Through ICU stay, up to hospital discharge (or death)

• Requirement for inotropic support in non-survivors

  Through ICU stay, up to hospital discharge or death

• Hospital length of stay in non-survivors

  From hospital admission through study completion( up to discharge or death)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients (≥18 years) admitted to and treated in the Burn Intensive Care Unit.

You may qualify if:

• Patients aged 18 years and older
• Admitted to and treated in the Burn Intensive Care Unit

You may not qualify if:

• Patients with an ICU stay of less than 24 hours
• Patients younger than 18 years
• Patients with known chronic kidney disease or history of kidney transplantation
• Patients admitted with toxic epidermal necrolysis (TEN)
• Patients with estimated glomerular filtration rate (eGFR) ≤ 15 mL/min/1.73m² at admission

Sponsors & Collaborators

• Pinar Timur Tasci: lead

Study Sites (1)

Dr. Lutfi Kirdar City Hospital, Department of Anesthesiology and Reanimation

Istanbul, 34865, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Burns; Acute Kidney Injury; Critical Illness

Condition Hierarchy (Ancestors)

Wounds and Injuries; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Elif Bombaci, MD

  Dr.Lutfi Kirdar City Hospital, Department of Anesthesiology and Reanimation, İstanbul, Turkey

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Resident Physician, Department of Anesthesiology and Reanimation

Study Record Dates

• First Submitted: September 14, 2025
• First Posted: September 26, 2025
• Study Start: January 1, 2021
• Primary Completion: January 1, 2024
• Study Completion: January 1, 2024
• Last Updated: September 26, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)