CO2 Fractional Laser With Tranexamic Acid As An Effective Tool For Post Burn Hyperpigmentation.

NCT07195539 | Enrolling By Invitation

• 1 other identifier: 388/RC/KEMU
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

It will be a case within control trial. After IRB approval patients presenting with more than 6 months old hyperpigmented burn scars will be included in this study. All data (including age, gender, mode of burn) will be recorded on a proforma and standardized pre-intervention photographs will be taken. The hyperpigmented scar will be divided into two equal halves.One half will receive fractional CO2 wit TXA solution other half will receive fractional CO2 Laser with N/S solution.Thus allocation will be done randomly with the lottery method. Total 3 sessions of LADD will be done with 1 month interval between each session. The following settings will be used: probe frequency 75Hz; Power range 12-15W; dwell time 300 micros-500 micros, stach 1-2 and spacing 900-1200m. The TXN solution will be prepared by mixing 250mg of TXA in 5ml of N/S creating a 5% TXN solution. Standardized photographs will again be taken 3 months after the 3rd session. The pre- and post-treatment photographs will be assessed by Skin Hyperpigmentation Index (SHI) using a smartphone dermatoscope adapter and an online calculator, freely available at: https://shi.skini magea nalys is.com, can be used. 15. Any complications during treatment will be noted and documented. Patient satisfaction wil be measured on a Likert scale of 1-5.

Conditions

Post Burn Hyperpigmentation

Keywords

fractional ablative laser; tranexamic acid; post burn hyperpigmentation

Outcome Measures

Primary Outcomes (2)

• improvement in hyperpigmentation

  3 months after completion of sessions

• hyperpigmentation

  Skin Hyperpigmentation Index will be used to determine improvement in hyperpigmentation.

  3months after completion of sessions

Study Arms (1)

hyperpigmented lesion divided into halves and one for tranexamic acid one for saline

EXPERIMENTAL

this will be a split face study, each lesion will be divided into 2 halves one half will receive tranexamic acid spray while other will receive saline spray. each patient will act as his own control.

Other: Tranexamic Acid sprinkle with CO2 LASER

Interventions

Tranexamic Acid sprinkle with CO2 LASER OTHER

tranexamin acid will be sprayed after CO2 LASER

hyperpigmented lesion divided into halves and one for tranexamic acid one for saline

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age more than 18y
• Hyperpigmented Burn scar presenting after 6 months
• Patients with burn scar on face, neck, hands

You may not qualify if:

• Previous laser treatment
• Coagulation or platelet disorder
• Patients on anticoagulant medications/birth control pills
• DM/Connective tissue disorder
• Active viral infection
• History of malignancy/chemotherapy.

Sponsors & Collaborators

• King Edward Medical University: lead

Study Sites (1)

King Edward Medical University

Lahore, Punjab Province, 54000, Pakistan

Location

Related Publications (1)

• Schaffrick L, Ding J, Kwan P, Tredget E. The dynamic changes of monocytes and cytokines during wound healing post-burn injury. Cytokine. 2023 Aug;168:156231. doi: 10.1016/j.cyto.2023.156231. Epub 2023 May 27.

  PMID: 37247448 BACKGROUND

Related Links

• SHI will be used to measure improvement in hyperpigmentation

MeSH Terms

Interventions

Lasers, Gas

Intervention Hierarchy (Ancestors)

Lasers; Optical Devices; Equipment and Supplies; Radiation Equipment and Supplies

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Senior Registrar

Model Details: same patient will be receiving both treatments on different parts.each participant act as their own control

Study Record Dates

• First Submitted: September 9, 2025
• First Posted: September 26, 2025
• Study Start: June 1, 2025
• Primary Completion: January 30, 2026
• Study Completion: February 28, 2026
• Last Updated: December 1, 2025

Record last verified: 2025-06

Locations

PA (1)