Efficacy of Olfactive Training on Loss of Smell and Taste Caused by SARS CoV2 COVID-19 (Covid-Smell)

NCT07190911 | Completed

• 2 other identifiers: PAP_RI2_2020/172020-A02606-33
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to evaluate efficiency of two months of olfactive training on olfactory and taste loss secondary to covid-19. We will compare 2 groups : olfactive training group versus no olfactive training group.

Conditions

COVID - 19

Keywords

Covid-19; olfactory training; olfactory and taste loss

Outcome Measures

Primary Outcomes (1)

• Taste and Smell Survey (TSS).

  Patients will have this auto evaluation scale at the inclusion (D0) and 2 month after inclusion (D60).

  Baseline and 2 months

Secondary Outcomes (2)

• Sniffin' stick test :

  2 month

• Olfaction and taste evolution evaluated with a daily visual scale

  Every day from inclusion to 2 months

Study Arms (2)

olfactory training arm

EXPERIMENTAL

with a daily olfactory training during 2 month

Other: Olfactory rehabilitation consists of smelling a series of spices every day for 2 months

no olfactory training

NO INTERVENTION

Interventions

Olfactory rehabilitation consists of smelling a series of spices every day for 2 months OTHER

Olfactory rehabilitation consists of smelling a series of spices every day for 2 months: vanilla, coffee, dill, thyme, cinnamon, cloves, lavender, coriander, light vinegar, mint, and cumin. This rehabilitation is based on the protocols proposed by SFORL (French ORL society) and Oleszkiewicz et al.8 Allergies to certain spices will be noted at the start of the study: * in known allergy: change by another spice which belongs to the same chemical category. * in case of allergies to several scents: patient is not included in the study. * in case of allergy appearing during participation: clinical evaluation by ENT, change by another spice which belongs to the same chemical category. * in case of allergies to several scents occuring during participation: patient is excluded from the study.

olfactory training arm

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• SARS-CoV-2 infection suspect or confirmed
• supported by CHU Guadeloupe
• with brutal olfactory or taste loss
• affiliated or beneficiary of a social security scheme
• informed consent signed

You may not qualify if:

• recent rhinosinusitis, less than 6 months
• lingual pathology
• communication disorder
• Patients subject to a justice safeguard
• Allergy to several spices that are part of the rehabilitation set
• Pregnant or breastfeeding women
• Absence of signed consent

Sponsors & Collaborators

• Centre Hospitalier Universitaire de la Guadeloupe: lead

Study Sites (1)

Chu de La Guadeloupe

Pointe-à-Pitre, 97159, Guadeloupe

Location

Related Links

• Medical thesis of Ms. Nordera, entitled "Study on the Effectiveness of Olfactory Rehabilitation for Dysosmia and Dysgeusia Following SARS-CoV-2 Infection

MeSH Terms

Conditions

COVID-19; Anosmia; Ageusia

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Olfaction Disorders; Sensation Disorders; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Taste Disorders

Study Officials

• Suzy Duflo, MD PhD

  CHU de la Guadeloupe

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: CARE PROVIDER
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: To prove this efficiency, a parallel prospective comparative study appear to be one of the best the way.

Study Record Dates

• First Submitted: September 22, 2025
• First Posted: September 24, 2025
• Study Start: November 18, 2020
• Primary Completion: March 9, 2022
• Study Completion: March 9, 2022
• Last Updated: October 2, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

GU (1)