NCT07186712

Brief Summary

The aim of this study is to quantify the incidence of eTIC (defined as an elevated appt) and hyperfibrinolysis (defined as Ly30\>7) in early trauma patients. To identify patients at risk of eTIC and hyperfibrinolysis, we will conduct a systematic search for trauma patients with an ISS\>16 in whom a thrombelastogram (TEG) was obtained in the emergency department (ED)

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
263

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started May 2025

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 25, 2025

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

September 15, 2025

Completed
Same day until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 15, 2025

Completed
7 days until next milestone

First Posted

Study publicly available on registry

September 22, 2025

Completed
28 days until next milestone

Study Completion

Last participant's last visit for all outcomes

October 20, 2025

Completed
Last Updated

January 28, 2026

Status Verified

January 1, 2026

Enrollment Period

4 months

First QC Date

September 15, 2025

Last Update Submit

January 26, 2026

Conditions

Early Trauma Induced CoagulopathyTic

Keywords

eTICcoagulopathytrauma

Outcome Measures

Primary Outcomes (1)

  • incidence of eTIC

    defined by increased appt/INR

    1 hour after admission

Secondary Outcomes (3)

  • incidence of hyperfibrinolysis

    1 hour after admission

  • Correlation of standard laboratory abnormalities and TEG findings

    1 hour after admission

  • Correlation of eTIC and mortality

    30 days

Study Arms (1)

Patients in the trauma resuscitation bay of the Medical University of Graz

Valid thrombelastogramm available

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

patients with severe trauma (ISS\>16)

You may qualify if:

  • Age \< 18 years
  • Sever trauma (ISS\>16)
  • Coagulation parameters (PT, aPTT, INR, fibrinogen, TEG) available within the first hour of admission

You may not qualify if:

  • Patients with known pre-existing coagulopathies
  • Patients on anticoagulant therapy prior to trauma
  • Incomplete or missing coagulation data

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Medical University of Graz

Graz, 8043, Austria

Location

MeSH Terms

Conditions

TicsHemostatic DisordersWounds and Injuries

Condition Hierarchy (Ancestors)

DyskinesiasNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and SymptomsVascular DiseasesCardiovascular DiseasesHemorrhagic DisordersHematologic DiseasesHemic and Lymphatic Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 15, 2025

First Posted

September 22, 2025

Study Start

May 25, 2025

Primary Completion

September 15, 2025

Study Completion

October 20, 2025

Last Updated

January 28, 2026

Record last verified: 2026-01

Locations

AU(1)