Specific Dietary Fibers May Enhance Colonic Adaptation in Short Bowel Syndrome Through Microbial and Metabolic Mechanisms That Drive Functional Compensation.

NCT07186608 | Completed

• 1 other identifier: 20250918
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

Ten patients with short intestines in clinical practice were intervened with dietary fiber. Serum and feces before and after the dietary fiber intervention were collected, and relevant indicators of nutrition and intestinal barrier were collected to observe the improvement of dietary fiber on patients with short intestines

Conditions

Short Bowel Syndrome

Outcome Measures

Primary Outcomes (1)

• Determination of nitrogen content

  From enrollment to the end of treatment at 2 weeks

Study Arms (1)

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EXPERIMENTAL

Dietary Supplement: Dietary fiber intervention

Interventions

Dietary fiber intervention DIETARY_SUPPLEMENT

Ten patients with short bowel syndrome in clinical practice were subjected to dietary fiber intervention. Blood and fecal samples were collected before and after the dietary fiber intervention, and nutritional and intestinal barrier-related indicators were also collected to observe the improvement effect of dietary fiber on these patients.

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Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

All participants in Cohort 1 were recruited at the Eastern Theatre Command General Hospital (Nanjing, China) and provided written informed consent. The primary inclusion criterion was a confirmed diagnosis of type II or type III short bowel syndrome in patients aged 18 -70 years. Participants were excluded if they had other gastrointestinal diseases, malignant tumours, autoimmune diseases, infectious diseases or renal insufficiency (severe kidney disease with creatinine levels exceeding 3.0 mg/dL), or if they had taken antibiotics for more than three days within the preceding three months.

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Sponsors & Collaborators

• Jinling Hospital, China: lead

Study Sites (1)

Eastern Theater Command General Hospital

Nanjing, China

Location

MeSH Terms

Conditions

Short Bowel Syndrome

Condition Hierarchy (Ancestors)

Malabsorption Syndromes; Intestinal Diseases; Gastrointestinal Diseases; Digestive System Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Chief Physician

Study Record Dates

• First Submitted: September 19, 2025
• First Posted: September 22, 2025
• Study Start: February 5, 2025
• Primary Completion: August 15, 2025
• Study Completion: August 15, 2025
• Last Updated: September 22, 2025

Record last verified: 2025-09

Locations

CN (1)