Mechanistic Study of SPARC-Mediated Regulation of Neutrophil Extracellular Trap Formation in the Brain Metastatic Microenvironment of Breast Cancer

NCT07185646 | Active Not Recruiting

• 1 other identifier: 32200747
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of this observational study is to investigate the characteristics of the tumor microenvironment in patients with brain tumors using multi-modal magnetic resonance imaging (MRI). The primary research question it aims to address is: • Can multi-modal MRI effectively characterize features of the immune microenvironment in brain tumor patients? Participants: Eligible participants who have been diagnosed with a brain tumor will undergo multi-modal MRI scans for detailed assessment of tumor microenvironment features.

Conditions

Neuro-Oncology; MRI Imaging; Tumor Immune Microenvironment

Outcome Measures

Primary Outcomes (1)

• Postoperative Progression-Free Survival

  Postoperative Progression-Free Survival is defined as the time interval from the date of surgical intervention until the first occurrence of either documented disease progression or death from any cause

  6months，12months，24months

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with brain tumors

You may qualify if:

• conventional MRI revealed intracranial space-occupying lesions and suspected high-grade gliomas, brain metastases and meningiomas；
• It is planned to perform a brain tumor resection surgery in this institution.

You may not qualify if:

• other CNS diseases in addition to brain tumors;
• pathologically confirmed brain tumors not belonging to any of the three selected types;
• contraindications to the use of gadolinium contrast, including hypersensitivity to contrast agents, renal dysfunction, pregnancy or lactation;
• contraindications to MRI;
• poor image quality unsuitable for subsequent analyses;
• age younger than 18 years.

Sponsors & Collaborators

• Second Xiangya Hospital of Central South University: lead

Study Sites (1)

the Second Xiangya Hospital of Central South University

Changsha, Hunan, 410011, China

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Researcher

Study Record Dates

• First Submitted: September 15, 2025
• First Posted: September 22, 2025
• Study Start: January 1, 2023
• Primary Completion (Estimated): December 30, 2028
• Study Completion (Estimated): December 30, 2030
• Last Updated: September 23, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)