NCT07184463

Brief Summary

Pulmonary resections are key in treating lung neoplasms, with techniques adapted to tumor size and location. Minimally invasive approaches like VATS have replaced open thoracotomy, but intercostal trocar placement can lead to nerve injury and chronic pain. Robotic-assisted thoracic surgery (RATS) is usually done via a transthoracic (RATS-TT) approach using intercostal trocars. A newer "out of cage" method (RATS-OTC), using subcostal or subxiphoid ports, avoids intercostal access, potentially reducing nerve damage. A French study showed less opioid use and acute pain with RATS-OTC, but chronic pain outcomes are still unknown. At CHUM, a hybrid RATS technique (RATS-TTH) is also used-intercostal for instruments, but with out-of-cage specimen extraction-to limit intercostal trauma.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
120

participants targeted

Target at P50-P75 for all trials

Timeline
13mo left

Started Dec 2025

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress28%
Dec 2025Jun 2027

First Submitted

Initial submission to the registry

September 12, 2025

Completed
7 days until next milestone

First Posted

Study publicly available on registry

September 19, 2025

Completed
3 months until next milestone

Study Start

First participant enrolled

December 5, 2025

Completed
1.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2027

Last Updated

February 23, 2026

Status Verified

February 1, 2026

Enrollment Period

1.5 years

First QC Date

September 12, 2025

Last Update Submit

February 19, 2026

Conditions

Thoracic SurgeryVideo-assisted Thoracic SurgeryRobotic-assisted Thoracic Surgery

Keywords

chronic pain

Outcome Measures

Primary Outcomes (1)

  • Presence of persistent postoperative pain

    The presence of persistent postoperative pain, defined as ipsilateral chest pain (on the same side as the surgery) occurring at rest and/or with coughing on a daily basis. Assessed by a 'yes' or 'no' response when asked at 3 and 6 months postoperatively.

    3 and 6 months after surgery

Secondary Outcomes (9)

  • Occurrence of a neuropathic pain component

    3 and 6 months after surgery

  • Impact of chronic pain on overall recovery

    3 and 6 months after surgery

  • Preoperative analgesic use

    On the day of the surgery

  • Overall recovery

    3 and 6 months after surgery

  • Residual pain intensity

    3 and 6 months after surgery

  • +4 more secondary outcomes

Study Arms (1)

Pulmonary resections surgery with three surgical approaches:

RATS-OTC (no intercostal access) RATS-TT (intercostal instruments and specimen) RATS-TTH (intercostal instruments, out-of-cage specimen)

Other: Evaluation of chronic pain at 3 and 6 months after thoracic surgery

Interventions

Evaluation of chronic pain at 3 and 6 months after thoracic surgeryOTHER

The presence of persistent postoperative pain, defined as ipsilateral chest pain (on the same side as the surgery) occurring at rest and/or with coughing on a daily basis. Assessed by a 'yes' or 'no' response when asked at 3 and 6 months postoperatively.

Pulmonary resections surgery with three surgical approaches:

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients undergoing elective anatomical pulmonary resection (anatomical segmentectomy, lobectomy or bilobectomy) via minimally invasive approach (robotic).

You may qualify if:

  • Patients aged 18 years and older
  • American Society of Anesthesiologists (ASA) score 1-3

You may not qualify if:

  • Language barrier, psychiatric, physical or mental condition making pain assessment impossible despite prior education
  • Patient refusal to participate
  • Patients reoperated by VATS or thoracotomy in the postoperative period in the context of the occurrence of complications

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Centre Hospitalier de l'Université de Montreal

Montreal, Quebec, H2X 3E4, Canada

RECRUITING

MeSH Terms

Conditions

Chronic Pain

Condition Hierarchy (Ancestors)

PainNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Alex Moore, MD

    CHUM

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Alex Moore, MD

CONTACT

514-890-8000alex.moore.med@ssss.gouv.qc.ca

Julie Desroches, PhD

CONTACT

514-890-8000anesthesie.recherche.chum@ssss.gouv.qc.ca

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
OTHER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 12, 2025

First Posted

September 19, 2025

Study Start

December 5, 2025

Primary Completion (Estimated)

June 1, 2027

Study Completion (Estimated)

June 1, 2027

Last Updated

February 23, 2026

Record last verified: 2026-02

Locations

CA(1)