Clinical Efficacy of NST With Adjunctive Local Delivery of Ozonated Olive Versus Curcumin Gel in Stage II Grade B Periodontitis.

NCT07184268 | Completed DMC

• 1 other identifier: 892025
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this clinical trial is to evaluate the effectiveness of local delivery ozonated olive gel versus curcumin gel as adjunct to scaling and root planing in the treatment of stage II grade B periodontitis in on both males and females in the age group between 18 and 50 years. outcome measures are Clinical attachment level (CAL), plaque index (PI), gingival index (GI).

Conditions

Periodontitis, Adult

Keywords

Nonsurgical therapy; local delivery gel; curcumin gel; ozonated olive oil; molar incisor pattern periodontitis; Chronic periodontitis; stage II grade B

Outcome Measures

Primary Outcomes (1)

• Clinical attachment level

  measured from the cementoenamel junction (CEJ) to the bottom of pocket.

  3 months

Secondary Outcomes (2)

• Gingival Index

  3 months

• Plaque index

  3 months

Study Arms (2)

curcumin gel

ACTIVE COMPARATOR

The curcumin gel will be gently deposited into the periodontal pockets to ensure adequate subgingival delivery.

Procedure: full mouth non-surgical scaling

ozonated olive gel.

ACTIVE COMPARATOR

patients will receive subgingival application of ozonated olive oil in the periodontal pocket

Procedure: full mouth non-surgical scaling

Interventions

full mouth non-surgical scaling PROCEDURE

All patients will receive a full mouth scaling using ultrasonic scalers and hand instrumentation

curcumin gel; ozonated olive gel.

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patients diagnosed with stage II periodontitis defined by having interdental CAL 3-4 mm and presence of pocket depth (PD) ≤ 5 mm, and grade B periodontitis characterized by a moderate rate of disease progression.
• Patients agree to a 3-month follow-up period and provide an informed consent.

You may not qualify if:

• Presence of prosthetic crowns, overhanging restorations and orthodontic treatment.
• Teeth with both endo-perio lesions.
• Antibiotics therapy that has an impact on the clinical signs and symptoms of periodontitis in the previous 3 months.
• Anti-inflammatory drugs in the previous 1 month.
• \. History of systemic disease, allergy, cardiovascular diseases, diabetes mellitus, hypertension, bleeding disorders, hyperparathyroidism, and compromised medical conditions, pregnant and lactating females.

Sponsors & Collaborators

• Cairo University: lead
• MTI University: collaborator

Study Sites (1)

Modern University for technology and information

Cairo, Egypt

Location

MeSH Terms

Conditions

Chronic Periodontitis

Condition Hierarchy (Ancestors)

Periodontitis; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Parryhan M Abdelsamie

  MTI University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of periodontology

Model Details: The test group "Group 1" will receive full Scaling and root planing (SRP) followed by subgingival application of ozonated olive gel. The control group "Group 2" will receive full-mouth SRP followed by subgingival application of curcumin gel

Study Record Dates

• First Submitted: September 8, 2025
• First Posted: September 19, 2025
• Study Start: November 2, 2025
• Primary Completion: March 15, 2026
• Study Completion: March 15, 2026
• Last Updated: March 19, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)