Comparison of Dwell Time of Open Versus Closed Type Peripheral Intravenous Cannula

NCT07182877 | Completed DMC

• 1 other identifier: IEC-INT/2024/Study-2393
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Studies have shown that stabilisation devices are associated with fewer complications and lower failure rates in peripheral catheters.3,6,7 Although closed-system peripheral catheters offer potential advantages, such as reduced manipulation of components and minimised blood spillage, more research is needed to understand their impact on outcomes. The ability of peripheral catheters to remain functional and in place without complications is crucial. While various clinical factors influence peripheral catheter performance, the composition and structure of peripheral catheters also affect their dwell time, which is defined as the duration at which the catheter remains functional after insertion. A study by McNeill et al. found that during the preintervention phase, about 62% of open-system peripheral catheters lost IV access within 36 hours, with less than 10% remaining functional beyond 72 hours. The dwell time of closed-system peripheral catheters with a securement device increased to up to 96 hours during the intervention period.8

Conditions

Thrombophlebitis

Keywords

IV cannula, thrombophlebitis

Outcome Measures

Primary Outcomes (2)

• Dwell time

  Time till cannula is used for dispensing drugs

  28 days

• Dwell time

  The time for which intravenous cannula is kept for dispensing drugs

  28 days

Secondary Outcomes (1)

• Catheter-related complications

  28 days

Study Arms (2)

Group 1

EXPERIMENTAL

Closed-type peripheral catheters

Device: Closed-type peripheral cannula

Group 2

ACTIVE COMPARATOR

Open-type peripheral catheters

Device: Open type peripheral cannula

Interventions

Closed-type peripheral cannula DEVICE

We will use closed-type peripheral catheters (BD Nexia Closed IV Catheter System.

Also known as: Closed cannula

Group 1

Open type peripheral cannula DEVICE

We will use POLYMED Ultra Intravenous cannula in the control arm

Also known as: Open cannula

Group 2

Eligibility Criteria

• Age: 12 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• All patients admitted to the intensive care unit and requiring intravenous cannulation for dispensing drugs

You may not qualify if:

• Patients with peripheral catheters inserted elsewhere before RICU admission
• Central venous catheters or other central vascular access devices
• those with RICU stay \< 24 hours will be excluded from the study
• Pregnancy

Sponsors & Collaborators

• Post Graduate Institute of Medical Education and Research, Chandigarh: lead

Study Sites (1)

Respiratory ICU, Department of Pulmonary Medicine, PGIMER

Chandigarh, 160012, India

Location

MeSH Terms

Conditions

Thrombophlebitis

Condition Hierarchy (Ancestors)

Venous Thrombosis; Thrombosis; Embolism and Thrombosis; Vascular Diseases; Cardiovascular Diseases; Phlebitis; Peripheral Vascular Diseases; Vasculitis

Study Officials

• Inderpaul S Sehgal, DM

  PGIMER, Chandigarh

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: Group allocation
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: Group 1: closed-type peripheral catheters Group 2: open-type peripheral catheters

Study Record Dates

• First Submitted: September 13, 2025
• First Posted: September 19, 2025
• Study Start: October 1, 2025
• Primary Completion: January 1, 2026
• Study Completion: January 31, 2026
• Last Updated: February 18, 2026

Record last verified: 2026-02

Locations

IN (1)