Effect of Dexmedetomidine Infusion on Post Anesthesia Discharge Time

NCT07180810 | Completed

• 1 other identifier: IRB-23-14
• Study Type: interventional
• Target: 82
• Locations: 1 country
• Sites: 1

Brief Summary

A randomised control trial evaluating the effect of low dose dexmedetomidine infusion on post anesthesia discharge time in patients of day case breast cancer surgery compared with placebo infusion. The primary outcome was to compare the frequency of early discharge in each group.

Conditions

Post Anesthesia Discharge Time in Patients of Breast Cancer Surgery

Keywords

Breast cancer surgery, Dexmedetomidine, Post anesthesia discharge time

Outcome Measures

Primary Outcomes (1)

• Frequency of early discharge

  post anesthesia discharge time within 2 hours

  120 minutes

Study Arms (2)

Group A, receiving low dose dexmedetomidine infusion

EXPERIMENTAL

Group A, receiving low dose dexmedetomidine infusion at 0.6mcg/kg/hour rate

Drug: Dexmedetomidine infusion low dose

Group B, receiving normal saline infusion as placebo

PLACEBO COMPARATOR

normal saline being used as placebo at rate 0.6mch/kg/hour rate

Drug: Group B receiving normal saline

Interventions

Dexmedetomidine infusion low dose DRUG

low dose dexmedetomidine infusion at rate 0.6mcg/kg/hour rate .

Group A, receiving low dose dexmedetomidine infusion

Group B receiving normal saline DRUG

Normal saline infusion at rate 0.6mcg/kr/hour rate

Group B, receiving normal saline infusion as placebo

Eligibility Criteria

• Age: 18 Years - 60 Years
• Gender Eligibility Details: Female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age 18-60 yrs, ASA 1 and 2, elective breast cancer surgery

You may not qualify if:

• BMI greater than 35, CKD stage 3 or greater, known drug allergy to study drug, bradycardia, history of PONV, patients on antiepileptics

Sponsors & Collaborators

• Shaukat Khanum Memorial Cancer Hospital & Research Centre: lead

Study Sites (1)

Shaukat Khanum Memorial Cancer Hospital and Research Centre

Lahore, Pubjab, 54782, Pakistan

Location

Related Links

• Reference study from which sample size was calculated

Study Officials

• Almas nil Iqbal, FRCA

  Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, CARE PROVIDER
• Masking Details: Double blinded study, all participants, and the care provider providing anesthesia to the participants were blinded
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Group A being administered low dose intravenous dexmedetomidine infusion vs Group B being admissions IV normal saline infusion at rate 0.6mcg/kg/hour rate

Study Record Dates

• First Submitted: September 12, 2025
• First Posted: September 18, 2025
• Study Start: September 5, 2023
• Primary Completion: August 20, 2025
• Study Completion: August 20, 2025
• Last Updated: September 23, 2025

Record last verified: 2023-08

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)