National Registry of Hepatic Metastases From Non-Colorectal Cancer"

NCT07180641 | Completed

• 1 other identifier: 2023.238
• Study Type: observational
• Target: 1,039
• Locations: 0 countries
• Sites: N/A

Brief Summary

The investigators designed this observational, retrospective, multicenter study including all patients who underwent surgery for non-colorectal liver metastases between January 2010 and December 2022, with the aim of establishing a series of recommendations for the treatment of liver metastases from various extrahepatic primary tumors

Conditions

Non-colorectal Liver Metastasis; Liver Metastasis; Non-neuroendocrine Liver Metastasis; Liver Metastases; Non-colorectal Liver Metastases; Non-neuroendocrine Liver Metastases; Liver Resection; Hepatectomy

Keywords

Non-colorectal non-neuroendocrine liver metastases; Liver metastases; Liver resection; Hepatectomy

Outcome Measures

Primary Outcomes (2)

• Overall Survival

  Time from the date of liver resection for non-colorectal metastases to death from any cause. Survival will be assessed for up to 5 years postoperatively

  5 years from liver resection

• Progression-Free Survival

  Time from the date of liver resection for non-colorectal metastases to the date of documented disease progression or death from any cause, whichever occurs first. Patients without progression or death will be censored at the last follow-up

  5 years from surgery

Secondary Outcomes (5)

• Postoperative Morbidity Rate

  90 days from surgery

• Postoperative Mortality Rate

  90 days from surgery

• Recurrence Pattern

  Up to 5 years from liver resection

• Length of hospital stay

  Perioperative/Periprocedural

• R0 Resection Rate

  At surgery

Study Arms (1)

Patients with non-colorectal liver metastases

Patients who underwent liver resection for non-colorectal liver metastases from January 2010 to December 2022

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients scheduled for liver surgery due to non-colorectal liver metastases, regardless of the primary tumor origin, via open or minimally invasive approach, from January 2010 to December 2022

You may qualify if:

• Patients scheduled for liver surgery due to non-colorectal liver metastases, regardless of the primary tumor origin, via open or minimally invasive approach

You may not qualify if:

• Patients undergoing surgery for colorectal liver metastases, emergency surgical interventions and patients younger than 18 years old.

Sponsors & Collaborators

• Clinica Universidad de Navarra, Universidad de Navarra: lead

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 25, 2025
• First Posted: September 18, 2025
• Study Start: January 1, 2010
• Primary Completion: December 31, 2022
• Study Completion: December 31, 2022
• Last Updated: September 18, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
• Time Frame: 5 years following the end of recruitment, which was June 2025
• Access Criteria: All investigators who have participated in this multicenter study and who have expressed interest in its follow-up and execution.