Arlington Longitudinal Optimal Healthy Aging Study (ALOHA)

NCT07180147 | Active Not Recruiting

• 2 other identifiers: MUIRB#1238Potomac Health Foundation
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

The Arlington Longitudinal Optimal Healthy Aging (ALOHA) Study is a community-based research project led by the Marymount University Center for Optimal Aging (MCOA). The study is designed to help older adults in the Washington, D.C., Maryland, and Virginia (DMV) area maintain independence, mobility, wellbeing and brain health as they age. Adults aged 50 years and older will receive a comprehensive health assessment at the study site, Center for Optimal Aging- ALOHA Lab at Marymount University (MU) Ballston Campus in Arlington, Virginia. The assessment includes physical and cognitive testing, health and medical history, lifestyle surveys, and biometric measures such as blood pressure, grip strength, body composition by the InBody system, balance and gait speed. Participants will receive their results in a personalized "Health Passport," which summarizes findings and provides tailored recommendations to help manage modifiable health risk factors-such as those linked to Alzheimer's disease, cardiovascular disease, frailty syndrome, and depression. Participants will return annually for up to 5 years to repeat assessments and receive updated health and wellness recommendations. The study will track changes in health over time and explore the impact of the Health Passport on health behaviors, functional independence, and quality of life. ALOHA will also evaluate the cultural appropriateness of the Health Passport for diverse populations in Northern Virginia. The program incorporates an interprofessional research model, engaging researchers from multiple health professions to work alongside older adults, supporting both participants' wellness and optimal aging.

Conditions

Cardio Vascular Disease; Mild Cognitive Impairment (MCI); Frailty Syndrome; Disability Physical; Metabolic Syndrome (MetS); Healthy Aging; Alzheimer Disease (AD); Hypertension; Obesity &Amp; Overweight

Keywords

Optimal aging; dementia risk factors; Cardiovascular Health; Healthy Aging; Alzheimer Disease Prevention; Lifestyle Intervention; Dementia Risk Reduction; Cognitive Aging; Brain Health; Falls Prevention; Physical Function; Functional Independence; Frailty Prevention; Modifiable Risk Facators

Outcome Measures

Primary Outcomes (2)

• Change in adherence to Health Passport recommendations-Physical/Cardiovascular Health (HPAI-PC)

  Health Passport Adherence Index (HPAI) Physical/Cardiovascular health; study-specific index. 5-item Likert index (0-4 per item), domain total 0-20; higher = better adherence. Unit: points.

  Baseline and 12 months (with annual re-testing up to 5 years, per protocol).

• Change in adherence to Health Passport recommendations-Cognitive, Sleep, and Mental Health (HPAI-CSM)

  Health Passport Adherence Index (HPAI) for Cognitive, Sleep and Mental Health. 5-item Likert index (0-4 per item), domain total 0-20; higher = better adherence. Unit: points.

  Baseline and 12 months (with annual re-testing up to 5 years, per protocol).

Secondary Outcomes (25)

• Change in Montreal Cognitive Assessment (MoCA) score

  Baseline and 12 months (with annual re-testing up to 5 years, per protocol).

• Change in static balance (Four-Stage Balance Test)

  Baseline and 12 months (with annual re-testing up to 5 years, per protocol).

• Change in adherence to Health Passport recommendations-Diet and Oral Health (HPAI-DO)

  Baseline and 12 months (with annual re-testing up to 5 years, per protocol).

• Change in adherence to Health Passport recommendations-Social Health (HPAI-SH)

  Baseline and 12 months (with annual re-testing up to 5 years, per protocol).

• Change in walking endurance (200-Meter Fast Walk Test)

  Baseline and 12 months (with annual re-testing up to 5 years, per protocol).

Other Outcomes (7)

• Change in food insecurity (A-SDH)

  Baseline and 12 months (with annual re-testing up to 5 years, per protocol).

• Change in transportation difficulty (A-SDH)

  Baseline and 12 months (with annual re-testing up to 5 years, per protocol).

• Overall adherence to Health Passport recommendations (HPAI total; exploratory)

  Baseline and 12 months (with annual re-testing up to 5 years, per protocol).

Study Arms (1)

ALOHA Health Passport Cohort

Community-dwelling adults aged 50 and older who receive a comprehensive baseline and annual health assessment at the Marymount University Center for Optimal Aging. Assessments include physical, cognitive, and psychosocial measures. Results are compiled into a personalized "Health Passport" with tailored recommendations for managing modifiable health risk factors. Participants return annually for up to 5 years to monitor health changes, update recommendations, and complete follow-up surveys on adherence and outcomes.

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Community-dwelling adults aged 50 years and older living in the Washington, D.C., Maryland, and Virginia metropolitan area. Participants are generally healthy or have manageable chronic conditions and are able to complete physical, cognitive, and psychosocial assessments. Recruitment will emphasize diversity, including racial/ethnic minority groups and individuals from underserved communities, with study materials available in English and Spanish.

You may qualify if:

• Age 50 years or older at time of enrollment
• Residing in the Washington, District of Columbia (DC)., Maryland, or Virginia metropolitan areas
• Community-dwelling (living independently or with minimal assistance)
• Able to participate in physical and cognitive assessments
• Able to provide informed consent
• Willing to return for annual follow-up assessments for up to 5 years

You may not qualify if:

• Diagnosis of dementia or significant cognitive impairment that prevents informed consent or participation in assessments
• Severe physical disability or medical condition that precludes participation in study assessments (e.g., unstable cardiac condition, severe mobility limitation)
• Current diagnosis of a terminal illness with life expectancy less than 12 months
• Residing in a long-term care facility or nursing home at time of enrollment
• Inability to communicate in English or Spanish (study materials available in these languages only)
• Participation in another interventional trial that could confound study results

Sponsors & Collaborators

• Potomac Health Foundations: collaborator
• Marymount University: lead

Study Sites (1)

Center for Optimal Aging, Marymount University

Arlington, Virginia, 22201, United States

Location

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Related Links

• The Arlington Longitudinal Optimal Healthy Aging Study is a research initiative led by health experts at Marymount University. This timely study provides a comprehensive academic-to-community health program designed to enhance old wellbeing.
• Join the ALOHA Study and Help Us Understand Optimal Aging in the DMV Area!

MeSH Terms

Conditions

Alzheimer Disease; Cognitive Dysfunction; Frailty; Hypertension; Metabolic Syndrome; Obesity; Overweight

Condition Hierarchy (Ancestors)

Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders; Cognition Disorders; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Vascular Diseases; Cardiovascular Diseases; Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Overnutrition; Nutrition Disorders; Body Weight; Signs and Symptoms

Study Officials

• Patricia C Heyn, PhD, FGSA, FACRM

  Office of Research, Marymount University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Vice President for Research

Study Record Dates

• First Submitted: August 15, 2025
• First Posted: September 18, 2025
• Study Start: May 1, 2025
• Primary Completion (Estimated): December 30, 2030
• Study Completion (Estimated): July 30, 2031
• Last Updated: March 9, 2026

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
• Time Frame: IPD will be available immediately following the publication of study results. Results will be made available indefinitely via an appropriate public repository.

Locations

US (1)