Discontinuous Echocardiographic Subcostal Cardiac Output Measurement

NCT07177391 | Recruiting

• 2 other identifiers: 2024/0200/OB2024-A01706-41
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Cardiac output (CO) monitoring is recommended for the most serious and multiple-failure patients in critical care and allows the diagnosis of acute circulatory failure as well as its etiology and also allows the monitoring of treatments. However, although allowing an adaptation of hemodynamic treatments and being integrated into a therapeutic personalization approach in situations of acute circulatory failure, the measurement of CO is conditioned by the availability of devices, by their sometimes problematic invasiveness, as well as their cost. In addition, the discontinuous measurement of CO by echocardiography is made difficult in the context of resuscitation with patients who are less mobilizable and less echogenic.

Conditions

Cardiac Output Measurement

Keywords

diagnosis of circulatory failure; multiple failures in critical care

Outcome Measures

Primary Outcomes (1)

• Measurement of Cardiac Output (CO) via the subcostal route

  To assess the concordance of the measurement of cardiac output in the ejection chamber of the right ventricle (DC-CEVD, innovative method) with that of cardiac output in the ejection chamber of the left ventricle (DC-CEVG, reference method) on subcostal transthoracic ultrasound (TTE).

  At Enrollment visit and DAY 28

Secondary Outcomes (3)

• Compare the measurement success rate of DC-CEVD to that of DC-CEVG.

  At Enrollment visit and DAY 28

• To assess the concordance of DC variation during preload-dependence search maneuvers (passive leg raise) in intubated and ventilated patients between DC-CEVD and DC-CEVG measurements.

  At Enrollment visit and DAY 28

• DC measurement by transpulmonary thermodilution device

  At Enrollment visit and DAY 28

Interventions

Discontinuous subcostal echocardiographic cardiac output assessment OTHER

Right Ventricular Outflow Chamber Diameter (RVOD) and Left Ventricular Outflow Chamber Diameter (LVOD) assessments via subcostal approach

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This is a prospective cohort including patients admitted to the intensive care unit of the Rouen University Hospital and requiring, upon admission or during their stay, the performance of a transthoracic echocardiography for diagnostic assessment and/or therapeutic monitoring.

You may qualify if:

• Adult patient (Age ≥ 18 years)
• Patient admitted to the intensive care unit at Rouen University Hospital.
• Transthoracic echocardiography (TTE) is required upon admission or during the patient's stay for diagnostic assessment and/or therapeutic monitoring.

You may not qualify if:

• Person deprived of liberty by an administrative or judicial decision or person placed under judicial protection/guardianship or curatorship
• Patient not affiliated with the social security system
• Refusal by the patient or trusted person if the patient is incapable of expressing consent
• Pregnant woman
• Dying patient

Sponsors & Collaborators

• University Hospital, Rouen: lead

Study Sites (1)

University Rouen Hospital

Rouen, 76031, France

RECRUITING

Central Study Contacts

Thomas TM MAUDHUIZON, Doctor

CONTACT

02 32 88 82 61; t.maudhuizon@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 9, 2025
• First Posted: September 17, 2025
• Study Start: November 25, 2024
• Primary Completion: September 9, 2025
• Study Completion: October 30, 2025
• Last Updated: September 17, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)