LUpus Eritematoso Sistemico NETwork and Registry
LUNET
The LUNET Project: the Italian Systemic Erythematous Lupus Network and Registry
1 other identifier
observational
1,500
1 country
16
Brief Summary
The LUNET Registry is intended to serve as a comprehensive primary data source, capturing real-world longitudinal clinical information, and the heterogeneity of patient presentations that are often underrepresented in traditional clinical trials. Ultimately, the LUNET Registry will help to optimize SLE management in routine clinical practice by enabling the compilation of real-world evidence to inform clinical decision-making and health policy. Patients will be enrolled by secondary and tertiary care centres for SLE across Italy in a real-world clinical set-up.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Sep 2025
Longer than P75 for all trials
16 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
September 9, 2025
CompletedFirst Posted
Study publicly available on registry
September 16, 2025
CompletedStudy Start
First participant enrolled
September 30, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 31, 2035
September 16, 2025
September 1, 2025
1.3 years
September 9, 2025
September 9, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Remission
Number of patients who achieved complete clinical remission or low disease activity
Every year to ten year
Disease activity
Changes in disease activity (SLEDAI-2k)
Every year to ten year
Eligibility Criteria
Patients with SLE according to the SLICC 2012 and/or ACR/EULAR 2019 classification criteria
You may qualify if:
- age ≥ 18 years;
- confirmed SLE diagnosis according to the SLICC 2012 and/or ACR/EULAR 2019 classification criteria;
- provision of signed written informed consent prior to participation
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (16)
SOD Clinica Medica, Dip. Medicina Interna- Ospedali Riuniti Marche-AOU delle Marche
Ancona, Italy
Medicina Interna Universitaria (Guido Baccelli) Azienda Ospedaliera Policlinico Consorziale
Bari, Italy
U.O. di Medicina, Ospedale Civile "Santa Maria della Sapienza"
Battipaglia, Italy
Allergologia e Immunologia Clinica, Azienda Ospedaliero-Universitaria di Cagliari
Cagliari, Italy
Struttura organizzativa Dipartimentale Complessa Immunologia e Terapie Cellulari, A.O.U. Careggi
Florence, Italy
Struttura complessa Allergologia Immunologia Clinica e Reumatologia.Azienda Socio Sanitaria Territoriale di Mantova
Mantova, Italy
Unità di Immunologia, Reumatologia, Allergologia e Malattie Rare all'IRCCS Ospedale San Raffaele di Milano
Milan, 20132, Italy
Division of Internal Medicine and Clinical Immunology, Azienda Ospedaliera Universitaria Federico II
Napoli, Italy
SYNERGO - Institute of Clinical Immunotherapy and Advanced Biological Treatmets-Casa di Cura Pierangeli S.r.l.
Pescara, Italy
UO Immunoallergologia clinica, Azienda Ospedaliero Universitaria Pisana
Pisa, Italy
UOC di Medicina Interna e Nutrizione Clinica -Policlinico Umberto I
Roma, Italy
Reumatologia e Immunologia Clinica, Humanitas Research Hospital
Rozzano, Italy
UOC Clinica Immunologica e Reumatologica, A.O.U. San Giovanni di Dio e Ruggi d'Aragona
Salerno, Italy
SC (U.C.O.) Medicina Clinica Azienda Sanitaria Universitaria Giuliano Isontina (ASU GI)
Trieste, Italy
SCDU Immunologia e Allergologia AO Ordine Mauriziano, University of Turin
Turin, 10128, Italy
Medicina Interna B - Azienda Ospedaliera Universitaria Integrata
Verona, Italy
Related Publications (1)
Mormile I, Brussino L, Canonica GW, Cortini F, Costantino MT, Dagna L, Del Giacco S, Della Casa F, Di Gioacchino M, Emmi G, Moroncini G, Negrini S, Pacella D, Parronchi P, Patella V, Rossi FW, Sirena C, Triggiani M, Vacca A, de Paulis A. The LUNET Project: Developing the Italian Systemic Erythematous Lupus Network. J Clin Med. 2025 Sep 2;14(17):6197. doi: 10.3390/jcm14176197.
PMID: 40943959BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Amato de Paulis
Division of Internal Medicine and Clinical Immunology, Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 10 Years
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 9, 2025
First Posted
September 16, 2025
Study Start
September 30, 2025
Primary Completion (Estimated)
December 31, 2026
Study Completion (Estimated)
December 31, 2035
Last Updated
September 16, 2025
Record last verified: 2025-09