Vascular Changes Associated With Endophthalmitis.

NCT07175311 | Recruiting DMC

• 1 other identifier: RE-24-26
• Study Type: observational
• Target: 71
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to describe and investigate vascular changes associated with exogenous endophthalmitis, as well as to create a photo library where they are evidenced

Conditions

Endophthalmitis

Keywords

Postoperative endophthalmitis; Multimodal imaging

Outcome Measures

Primary Outcomes (1)

• Best-Corrected Visual Acuity (BCVA)

  Best-Corrected Visual Acuity (BCVA) will be assessed according to the ETDRS guidelines. The test must be performed with the patient positioned 4 meters from the backlit panel, which must be calibrated to emit 85 cd/m². This procedure will be carried out by the retina fellow assigned to the case.

  The assessment will be performed at each visit (7 days and 1 month after meeting the inactivation criteria for endophthalmitis).

Secondary Outcomes (2)

• Fluorescein Angiography

  The procedure may be performed at all study visits (7 days and 1 month after meeting the inactivation criteria for endophthalmitis).

• Fundus Photography

  The procedure may be performed at all study visits (7 days and 1 month after meeting the inactivation criteria for endophthalmitis).

Interventions

Multimodal imaging findings DIAGNOSTIC_TEST

Fundus photography, Optical Coherence Tomography, and Fluorescein Angiography will be performed 7 days after meeting the criteria for inactivation of endophthalmitis, as outlined in the MEX-ESG guidelines. These imaging tests will be repeated one month after meeting the inactivation criteria.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The population will be patients of the retina and vitreous service of Asociación para Evitar la Ceguera en México, who have a complete clinical record (age, sex, pathological personal history, non-pathological personal history, heredofamilial history, ophthalmologic history, allergies, medications, ophthalmologic examination with visual acuity, intraocular pressure at each visit), signed informed consent and with a history of exogenous or endogenous endophthalmitis with clear resolution criteria and clear means one week and one month after meeting the resolution criteria to be able to perform fluorescein angiography at both visits.

You may qualify if:

• Patients with a history of endophthalmitis Diagnosis of Endophthalmitis
• Clinical symptoms: Pain, decrease in visual acuity, anterior chamber cells and/or vitreous turbidity, corneal edema, conjunctival hyperemia
• Laboratory studies: B-mode USG and or positive culture
• Patients who meet the endophthalmitis resolution criteria of the Mexican Endophthalmitis Study Group
• Patients with previously signed informed consent

You may not qualify if:

• Patients who have not signed the informed consent
• Patients under 18 years.
• Patients with endophthalmitis who do not meet the resolution criteria of the Mexican Endophthalmitis Study Group

Sponsors & Collaborators

• Asociación para Evitar la Ceguera en México: lead

Study Sites (1)

Hospital Asociación Para Evitar la Ceguera en México I.A.P.

Mexico City, 04030, Mexico

RECRUITING

MeSH Terms

Conditions

Endophthalmitis

Condition Hierarchy (Ancestors)

Eye Infections; Infections; Eye Diseases

Study Officials

• Raul Velez Montoya, MD

  Asociación para Evitar la Ceguera en México

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Raúl Velez Montoya, MD

CONTACT

(52) 55 5436 7335; rvelezmx@yahoo.com

Benjamín Aboytes Ríos, MD

CONTACT

4772329592; benaborivers@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Target Duration: 6 Weeks
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 29, 2025
• First Posted: September 16, 2025
• Study Start: November 1, 2024
• Primary Completion: February 1, 2026
• Study Completion: March 1, 2026
• Last Updated: September 16, 2025

Record last verified: 2025-09

Locations

ME (1)