Chromosomal Translocations in Chandigarh Police

NCT07174804 | Completed

• 1 other identifier: IEC-08/2019-1290
• Study Type: interventional
• Target: 203
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this Non-Randomized Control Trial is to evaluate the prevalence of chromosomal translocations in occupationally stressed subjects and the molecular impact of yoga on such translocations and DNA damage response and repair in security guards of Chandigarh Police. The main questions it aims to answer are: Does yoga has any role in alleviating chromosomal translocations in healthy but occupationally stressed subjects? Does practice of yoga has any impact on molecular markers related to DNA damage response and repair before and after Yoga intervention in highly stressed individuals? Researchers will compare Control Group and Yoga group before and after Yoga intervention. Participants will be divided into two groups Control Group and Yoga Group. Yoga Group will be given yoga intervention for 3 months, 5 days a week and for 65 minutes in a day. Control Group will follow their daily routine without following the intervention. Before and after the intervention, blood samples will be collected from the participants of both groups and analysed for chromosomal translocations and DDRR markers.

Conditions

Chromosomal Translocations

Outcome Measures

Primary Outcomes (1)

• Prevalence of t(14;18) translocations using Nested PCR method

  Both control and yoga group will be assessed for prevalence of chromosomal translocations t(14;18) before and after yoga (IAYT) intervention. This prevalence will be measured as relative band intensity for each individual and will be compared for before and after IAYT intervention, and also for between the groups after intervention.

  3 months

Secondary Outcomes (5)

• Cohen's Perceived Stress Scale

  3 months

• Six Letter Cancellation Test (SLCT)

  3 months

• Trail Making Test (TMT)

  3 months

• Serum cortisol level using enzyme-linked immunosorbent assay

  3 months

• Relative Telomere Length using Real-Time PCR

  3 months

Study Arms (2)

IAYT Group (Yoga Group)

EXPERIMENTAL

This group will be formed from highly stressed individuals and will follow yoga protocol as intervention for three months.

Other: Yoga (IAYT) Intervention

Control Group

NO INTERVENTION

This group will be formed from highly stressed individuals and will not follow yoga protocol as intervention.

Interventions

Yoga (IAYT) Intervention OTHER

Yoga practice for a period of three months

IAYT Group (Yoga Group)

Eligibility Criteria

• Age: 25 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Individuals scoring more than 15 points on Cohen's scale. Once these subjects' consent to enrol, each one of them will be coded to maintain anonymity.

You may not qualify if:

• Individuals with complications in co-morbid conditions like Diabetes, Cirrhosis, etc.
• Individuals of age less than 25 or more than 60 years.
• Individuals who do not consent to be a part of this study.
• Individuals who fail to comply with the yoga protocol in Intervention Group.

Sponsors & Collaborators

• Post Graduate Institute of Medical Education and Research, Chandigarh: lead
• Swami Vivekananda Yoga Anusandhana Samsthana: collaborator

Study Sites (1)

Postgraduate Institute of Medical Education and Research

Chandigarh, 160012, India

Location

MeSH Terms

Conditions

Translocation, Genetic

Interventions

Yoga; Methods

Condition Hierarchy (Ancestors)

Chromosome Aberrations; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Mind-Body Therapies; Complementary Therapies; Therapeutics; Spiritual Therapies; Exercise Movement Techniques; Physical Therapy Modalities; Investigative Techniques

Study Officials

• Sheetal Sharma

  Postgraduate Institute of Medical Education & Research, Chandigarh

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: September 3, 2025
• First Posted: September 16, 2025
• Study Start: November 1, 2021
• Primary Completion: February 28, 2022
• Study Completion: March 31, 2022
• Last Updated: September 16, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF
• Time Frame: September 2026 to December 2026
• Access Criteria: Access to individual participant data will be granted to qualified researchers affiliated with academic or non-profit institutions. Requests must include a research proposal describing the purpose of use. Requests will be reviewed by the principal investigator and must comply with local and international data protection regulations. Data will be shared under a data use agreement to ensure confidentiality and non-commercial use.

Locations

IN (1)