ANTIBIOTIC-RESISTANT ENTEROBACTERALES BLOODSTREAM INFECTIONS AND RISK FACTORS IN PATIENTS ADMITTED TO THE INTENSIVE CARE UNIT

NCT07172932 | Completed

• 1 other identifier: E1-21-2215
• Study Type: observational
• Target: 314
• Locations: 1 country
• Sites: 1

Brief Summary

In this study, we first aimed to reveal the resistance profile of Enterobacteriales bloodstream infections at our center. We evaluated data from patients with ESBL, colistin, and carbapenem resistance and identified resistance risk factors. We then reviewed our approach to managing the infection based on the results obtained.Patients were grouped according to resistance patterns and resistance status and compared retrospectively.

Conditions

Bloodstream Infections; Enterobacteriaceae Infections; Intensive Care (ICU); Antibiotic Resistant Infection

Keywords

Bloodstream Infections; esbl; carbapenem resistance; colistin resistance

Outcome Measures

Primary Outcomes (1)

• Prevalence of antibiotic resistance phenotypes (ESBL, carbapenem, colistin) among Enterobacterales bloodstream infection isolates.

  Prevalence of antibiotic resistance phenotypes (ESBL, carbapenem, colistin) among Enterobacterales bloodstream infection isolates.

  From January 2019 to December 2022

Secondary Outcomes (1)

• Identification of patient-related and clinical risk factors associated with antibiotic-resistant Enterobacterales bloodstream infections.

  2019-2022.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This retrospective study included adult patients who were hospitalized in the intensive care units (ICUs) of the Neurology-Orthopedics Building at Ankara City Hospital between September 2019 and December 2022. Eligible participants were aged 18 years or older and had a blood culture positive for Enterobacterales species during ICU stay, which was evaluated by an Infectious Diseases and Clinical Microbiology specialist as the causative pathogen.

You may qualify if:

• Age ≥ 18 years
• Isolation of an Enterobacterales species from a blood culture obtained during ICU stay
• The isolate considered as the causative pathogen by an Infectious Diseases and Clinical Microbiology specialist

You may not qualify if:

• Isolates not considered as causative pathogens
• Growth of a different pathogen in blood culture within ±72 hours of the index culture

Sponsors & Collaborators

• Ankara City Hospital Bilkent: lead

Study Sites (1)

Ankara Bilkent City Hospital

Çankaya, Ankara, 06800, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Sepsis; Enterobacteriaceae Infections

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Gram-Negative Bacterial Infections; Bacterial Infections; Bacterial Infections and Mycoses

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: specialist doctor

Study Record Dates

• First Submitted: September 8, 2025
• First Posted: September 15, 2025
• Study Start: September 1, 2019
• Primary Completion: September 30, 2022
• Study Completion: January 30, 2023
• Last Updated: September 15, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)