Pulmonary Function, Muscle Strength, and Functional Capacity in Minimally Invasive Cardiac Surgery

NCT07172529 | Active Not Recruiting

• 1 other identifier: 3dcd45b218264a9a
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to evaluate pulmonary function, respiratory muscle strength, peripheral muscle strength, and functional capacity in adult patients undergoing either minimally invasive cardiac surgery (via mini-thoracotomy) or conventional sternotomy for coronary artery bypass grafting (CABG) at Gülhane Training and Research Hospital.The main questions it aims to answer are: Does minimally invasive cardiac surgery preserve pulmonary function better than conventional sternotomy? Does minimally invasive cardiac surgery result in less respiratory and peripheral muscle weakness compared to conventional sternotomy? Researchers will compare patients undergoing minimally invasive surgery with those undergoing conventional sternotomy to determine differences in pulmonary function, respiratory muscle strength, peripheral muscle strength, and functional capacity. Participants will: Undergo preoperative and postoperative (day 4) assessments including spirometry, inspiratory/expiratory mouth pressure measurements, and peripheral muscle strength testing (handgrip, shoulder flexion/abduction, hip flexion, knee extension). Perform functional capacity tests (30-second sit-to-stand test, 6-minute walk test). Complete questionnaires assessing pain (McGill Pain Questionnaire) and fear of movement (Tampa Scale of Kinesiophobia).

Conditions

Cardiac Surgery; Muscle Weakness | Patient; Pulmonary Function; Functional Capacity

Keywords

cardiac surgery; muscle weakness; pulmonary function; kinesiophobia; functional capacity

Outcome Measures

Primary Outcomes (8)

• Change in Pulmonary Function - Forced Vital Capacity (FVC)

  Forced Vital Capacity measured by spirometry. Results will be reported in liters (L).

  Baseline [preoperative] and postoperative day 4)

• Change in Pulmonary Function - Forced Expiratory Volume in 1 second (FEV1)

  Forced Expiratory Volume in 1 second measured by spirometry. Results will be reported in liters (L).

  Baseline to postoperative day 4

• Change in Respiratory Muscle Strength - Maximal Inspiratory Pressure (MIP)

  Inspiratory muscle strength measured with mouth pressure device. Results will be reported in cmH₂O.

  Baseline [preoperative] and postoperative day 4

• Change in Respiratory Muscle Strength - Maximal Expiratory Pressure (MEP)

  Expiratory muscle strength measured with mouth pressure device. Results will be reported in cmH₂O.

  Baseline [preoperative] and postoperative day 4

• Change in Handgrip Strength

  Handgrip strength measured with handheld dynamometer. Results will be reported in kilograms (kg).

  Baseline to postoperative day 4

• Change in Knee Extension Strength

  Knee extension strength measured with handheld dynamometer. Results will be reported in kilograms (kg).

  Baseline to postoperative day 4

• Change in Functional Capacity - 30-Second Sit-to-Stand Test

  Number of repetitions performed during the 30-second sit-to-stand test. Results will be reported as number of repetitions.

  Baseline to postoperative day 4

• Change in Functional Capacity - 6-Minute Walk Distance

  Distance covered during the 6-minute walk test. Results will be reported in meters (m).

  Baseline to postoperative day 4

Secondary Outcomes (2)

• Change in Pain Intensity - McGill Pain Questionnaire

  Baseline and postoperative day 4

• Change in Kinesiophobia - Tampa Scale of Kinesiophobia (TSK-17)

  Baseline and postoperative day 4

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients (18-80 years) scheduled for elective coronary artery bypass grafting at Gülhane Training and Research Hospital, either via minimally invasive mini-thoracotomy or conventional sternotomy approach.

You may qualify if:

• Adults aged 18-80 years
• Scheduled for elective cardiac surgery via either minimally invasive approach (mini-thoracotomy) or conventional sternotomy at Gülhane Training and Research Hospital
• Able to provide written informed consent

You may not qualify if:

• Previous history of cardiac surgery
• Presence of orthopedic or neurological disorders affecting mobility or muscle strength
• Postoperative cerebrovascular event
• Requirement for mechanical ventilation \> 24 hours postoperatively
• Intensive care unit stay \> 48 hours

Sponsors & Collaborators

• Zehra Can Karahan: lead

Study Sites (1)

Atilim University

Ankara, 06830, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Muscle Weakness; Kinesiophobia

Condition Hierarchy (Ancestors)

Muscular Diseases; Musculoskeletal Diseases; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Phobic Disorders; Anxiety Disorders; Mental Disorders

Study Officials

• Zehra Can Karahan, PHD

  Atılım University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Asst. Prof.

Study Record Dates

• First Submitted: August 18, 2025
• First Posted: September 15, 2025
• Study Start: May 1, 2024
• Primary Completion: November 1, 2025
• Study Completion: November 1, 2025
• Last Updated: September 15, 2025

Record last verified: 2025-09

Locations

TU (1)