The Effect of Chlorhexidine Mouthwash on Postprandial Glucose Response in Healthy Individuals
1 other identifier
interventional
45
1 country
1
Brief Summary
The digestion of carbohydrates begins in the mouth through the salivary enzyme amylase which breaks food starches into maltose and disaccharides. The mouth also has a large community of microorganisms which include bacteria, fungi, viruses and protozoa that can also assist in the digestion of carbohydrates. Mouthwashes containing antibacterial compounds such as chlorhexidine are used to kill oral bacteria, but current evidence indicates that a majority of these bacteria are essential for human health. The aim of this study is to investigate whether chlorhexidine mouthwash can also affect the digestion of carbohydrates. At least 25 individuals will be recruited. Participants will visit the laboratory in two occasions. A saliva and blood sample (fingertip to measure blood glucose) will be taken at baseline. Then, using a randomized, cross-over and double-blind design, the participants will rinse their mouth for two minutes with a placebo or chlorhexidine mouthwash. Then, participants will eat 50 g of white bread and blood glucose will be measured (fingertips) every 30 min for the following 2 hours. Another saliva sample will be collected at the end of each test.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Jun 2022
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 8, 2022
CompletedFirst Submitted
Initial submission to the registry
September 11, 2025
CompletedFirst Posted
Study publicly available on registry
September 15, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 10, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2026
ExpectedSeptember 19, 2025
September 1, 2025
3.5 years
September 11, 2025
September 12, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Blood glucose
2 hours
Study Arms (2)
Chlorhexidine
EXPERIMENTALPlacebo
PLACEBO COMPARATORInterventions
Rinsing the mouth with chlorhexidine mouthwash for 2 minutes before consuming 50 g of carbohydrates
Rinsing the mouth with placebo mouthwash for 2 minutes before consuming 50 g of carbohydrates
Eligibility Criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Plymouth
Plymouth, Devon, PL4 8AA, United Kingdom
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Raul Bescos Garcia
University of Plymouth
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- SUPPORTIVE CARE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor in Human Nutrition & Physiology
Study Record Dates
First Submitted
September 11, 2025
First Posted
September 15, 2025
Study Start
June 8, 2022
Primary Completion
December 10, 2025
Study Completion (Estimated)
June 1, 2026
Last Updated
September 19, 2025
Record last verified: 2025-09