NCT07167602

Brief Summary

Hamstring shortening is common in athletes and often causes pain, limited flexibility, and reduced function, which negatively impact performance. Manual therapy techniques such as Active Release Therapy (ART) and Positional Release Therapy (PRT) are frequently used, but their comparative effectiveness remains unclear. This randomized, single-blinded clinical trial enrolled 74 athletes aged 18-35 years with hamstring shortening at the University of Lahore. Participants were randomly assigned to receive either PRT with conventional physiotherapy (hot pack, TENS, stretching, ankle pumps) or ART with the same physiotherapy protocol. Each group received two supervised sessions per week for four weeks. The primary outcomes were pain (Numeric Pain Rating Scale), range of motion (Popliteal Angle), and functional ability (Lower Extremity Functional Scale). The Active Knee Extension test was used as a secondary outcome. This study seeks to determine which manual therapy approach provides greater improvements in pain, flexibility, and function, with the goal of guiding evidence-based rehabilitation for athletes.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
74

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Jul 2025

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2025

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 29, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 29, 2025

Completed
6 days until next milestone

First Submitted

Initial submission to the registry

September 4, 2025

Completed
7 days until next milestone

First Posted

Study publicly available on registry

September 11, 2025

Completed
Last Updated

September 11, 2025

Status Verified

September 1, 2025

Enrollment Period

2 months

First QC Date

September 4, 2025

Last Update Submit

September 4, 2025

Conditions

Keywords

hamstring shortening, short hamstring syndrome, athlete, physiotherapy, manual therapy, active release therapy, positional release therapy

Outcome Measures

Primary Outcomes (3)

  • Hamstring flexibility (Popliteal Angle test)

    Hamstring flexibility was assessed with a universal goniometer during the Popliteal Angle test. Participants lay supine with the hip flexed to 90°, and the knee was extended until a stretch was felt. The angle between the thigh and lower leg was recorded; larger angles reflect greater hamstring tightness. This test is widely used to quantify hamstring shortening.

    Baseline and 4 weeks after intervention

  • Pain intensity (Numeric Pain Rating Scale, NPRS)

    Pain severity in the posterior thigh was measured using the Numeric Pain Rating Scale (NPRS), an 11-point scale ranging from 0 ("no pain") to 10 ("worst imaginable pain"). Participants reported their average pain over the preceding 24 hours. This outcome captures the degree of symptom relief experienced after either Positional Release Therapy or Active Release Therapy.

    Baseline and 4 weeks (end of intervention)

  • Lower extremity function (Lower Extremity Functional Scale, LEFS)

    Functional ability was measured using the LEFS, a 20-item patient-reported questionnaire assessing difficulty with daily and sports-related lower limb activities. Each item is scored from 0 ("extreme difficulty or unable to perform") to 4 ("no difficulty"), for a total score range of 0-80. Higher scores indicate better function. The LEFS has high reliability (0.85-0.99) and validity for musculoskeletal conditions.

    Baseline and 4 weeks after intervention

Secondary Outcomes (1)

  • Hamstring tightness (Active Knee Extension test, AKE)

    Baseline and 4 weeks after intervention

Study Arms (2)

Positional Release Therapy plus Conventional Physiotherapy

EXPERIMENTAL

Participants in this group first received conventional physiotherapy consisting of hot pack application (10 minutes), transcutaneous electrical nerve stimulation (15 minutes), passive hamstring stretching, and ankle pumps. After conventional therapy, Positional Release Therapy (PRT) was administered for the medial and lateral hamstrings. PRT involved positioning the muscle in shortened positions of comfort and applying gentle pressure with specific limb movements to facilitate relaxation, reduce neuromuscular tension, and relieve discomfort. Each session lasted approximately 50 minutes (35 minutes conventional therapy + 15 minutes PRT) and was delivered twice weekly for 4 weeks.

Behavioral: Positional Release TherapyOther: Conventional Physiotherapy

Active Release Therapy plus Conventional Physiotherapy

ACTIVE COMPARATOR

Participants in this group also received conventional physiotherapy consisting of hot pack application (10 minutes), transcutaneous electrical nerve stimulation (15 minutes), passive hamstring stretching, and ankle pumps. Following conventional care, Active Release Therapy (ART) was administered. ART involved applying longitudinal tension to the hamstring muscles while guiding the limb through specific ranges of motion, combined with brief isometric contractions of the hamstrings and quadriceps. This technique aimed to release adhesions, restore soft tissue mobility, and improve flexibility. Each session lasted approximately 50 minutes (35 minutes conventional therapy + 15 minutes ART) and was delivered twice weekly for 4 weeks.

Behavioral: Active Release TherapyOther: Conventional Physiotherapy

Interventions

A manual therapy technique applied to the medial and lateral hamstrings after conventional physiotherapy. In PRT, the affected muscle is placed in a position of maximal comfort and relative shortening, while gentle pressure and controlled joint movements are applied. This position is held for approximately 30 seconds and repeated three times per session. The method aims to decrease neuromuscular tension, reduce pain, and promote muscle relaxation through a reflexive response. Distinct from Active Release Therapy, PRT does not involve active contractions or longitudinal tension but instead relies on positioning and relaxation to achieve therapeutic effects.

Also known as: PRT, positional release technique
Positional Release Therapy plus Conventional Physiotherapy

A manual therapy technique applied to the hamstrings after conventional physiotherapy. ART combines therapist-applied longitudinal tension with patient movement and brief isometric contractions of both hamstrings and quadriceps. The limb is guided through specific ranges of motion to break down adhesions, restore tissue mobility, and improve flexibility. Unlike Positional Release Therapy, ART is an active technique requiring patient engagement through contractions and controlled movement against resistance, targeting scar tissue and myofascial restrictions.

Also known as: ART, active release technique
Active Release Therapy plus Conventional Physiotherapy

Hot pack, TENS, hamstring stretching, ankle pumps (common to both groups).

Active Release Therapy plus Conventional PhysiotherapyPositional Release Therapy plus Conventional Physiotherapy

Eligibility Criteria

Age18 Years - 35 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Participants with age between 18 to 35
  • Both genders
  • Athletes with BMI between 18.5 kg/m² and 29.9 kg/m².
  • Basketball, Football And Badminton Players.
  • Athletes who practices atleast 3 days per week.
  • Participants with Numeric pain rating scale values \> 4.
  • Participants with unilateral tightness of hamstring muscle with SLR \< 80° and AKE \< 125°

You may not qualify if:

  • Participants with any acute chronic hamstring strain or lower back pain.
  • Participants with leg length discrepancy.
  • Participants with a sedentary lifestyle.
  • Participants with upper motor neuron or lower motor neuron lesion.
  • Participants with any previous history of lower extremity injury in the past three months
  • Participants who are not willing to sign the consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Lahore - Teaching Hospital, University Institute of Physical Therapy

Lahore, Punjab Province, Pakistan

Location

Study Officials

  • Muhammad Asim Arif

    University Institute of Physical Therapy, University of Lahore

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Masking Details
This was a single-blinded trial. The outcomes assessor was blinded to group allocation and not involved in treatment delivery. Randomization was performed using sealed opaque envelopes, and group assignments were concealed from the assessor throughout data collection to minimize bias.
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: This study used a parallel assignment design in which 74 athletes with hamstring shortening were randomized into two equal groups. Group A received Positional Release Therapy combined with conventional physiotherapy, while Group B received Active Release Therapy combined with the same physiotherapy protocol.
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 4, 2025

First Posted

September 11, 2025

Study Start

July 1, 2025

Primary Completion

August 29, 2025

Study Completion

August 29, 2025

Last Updated

September 11, 2025

Record last verified: 2025-09

Locations