PPV for Predicting PIH in the Elderly

NCT07166562 | Not Yet Recruiting DMC

• 1 other identifier: LYF20240327
• Study Type: observational
• Target: 86
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this observational study is to investigate the predictive power of pulse pressure variability during forced inhalation（PPVfi） on the occurrence of hypotension in elderly patients after induction of general anesthesia. The main question it aims to answer is: Can the PPVfi predict the occurrence of hypotension in elderly patients after induction of general anesthesia? By recording the PPV of patients during forced inhalation before anesthesia induction, with the incidence of hypotension as the state variable and PPV as the test variable, the area under the ROC curve was calculated to determine the optimal threshold, sensitivity, and specificity of PPV.

Conditions

Hypotension on Induction

Keywords

Post-induction Hypotension; Pulse Pressure Variation

Outcome Measures

Primary Outcomes (1)

• Pulse Pressure Variation

  PPV in tidal and during forced inspiratory breathing

  Before induction

Secondary Outcomes (2)

• Systolic Pressure Variation

  Before induction

• blood pressure

  before and after induction

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Elderly patients without significant moderate to severe systemic comorbidities.

You may qualify if:

• American Society of Anesthesiologists (ASA) classification ≤ Grade III;Age ≥ 65 years old; Elective surgery; Patients who require invasive arterial blood pressure monitoring during surgery.

You may not qualify if:

• Presence of moderate or severe systemic diseases, such as heart failure, arrhythmias, valvular heart disease, pulmonary hypertension, severe pulmonary diseases (e.g., chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis), endocrine disorders, etc.;Preoperative systolic blood pressure (SBP) ≥160 mmHg, mean arterial pressure (MAP) ≥110 mmHg, or heart rate (HR) ≥120 beats per minute;Patients with comorbid psychiatric or neurological disorders, or communication impairments.

Sponsors & Collaborators

• Second Xiangya Hospital of Central South University: lead

Study Officials

• Zhang wenjie, master

  Department of Pain Management, Second Xiangya Hospital, Central South University, Changsha

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Wang yaping, phD

CONTACT

13607314476; wangyaping6568@csu.edu.cn

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 3, 2025
• First Posted: September 10, 2025
• Study Start: September 5, 2025
• Primary Completion: October 30, 2025
• Study Completion: November 15, 2025
• Last Updated: September 10, 2025

Record last verified: 2025-09