Diagnostic Yield of Cardiac CT to Detect Cardiac Thrombi in Acute Ischemic Stroke: an Individual Patient Data Meta-Analysis

NCT07165093 | Completed

• 1 other identifier: NL64139.018.18
• Study Type: observational
• Target: 3,940
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the AIS of HEARTS registry is to establish a database to collect, maintain and provide accessible individual patient data from international cohorts and to provide pooled analyses about the yield and value of cardiac computed tomography (CT), acquired during the initial stroke imaging protocol. The main analysis will investigate the diagnostic yield of cardiac CT to detect cardioembolic sources of stroke in acute ischemic stroke patients.

Conditions

Ischemic Stroke; Cardioembolic Stroke; Thrombus; Cardiac CT

Keywords

cardiac CT; ischemic stroke; cardioembolic stroke; cardioembolic sources; cardiac thrombus; imaging

Outcome Measures

Primary Outcomes (1)

• Proportion of patients with cardiac thrombus detected on acute cardiac CT.

  The proportion of patients with acute ischemic stroke that have a cardiac thrombus detected on cardiac CT.

  Baseline: the assessment of a cardiac thrombus is performed when the patient arrives at the Emergency Department and undergoes the acute stroke imaging protocol including a cardiac CT.

Secondary Outcomes (4)

• Comparison between cardiac CT and echocardiography for the detection of cardiac thrombi.

  An average of within 1 year: the investigators include echocardiography that is performed in routine stroke clinical care. This means that the time delay is dependent on various aspect of the local center.

• Follow up 90 days: mortality compared between patients with and without thrombus

  From stroke onset until 90 days follow-up

• Follow-up 90 days: recurrent stroke

  Stroke onset until 90 days follow-up

• Follow-up 90 days: outcome using modified rankin scale score

  Stroke onset until 90 days follow-up

Study Arms (4)

Amsterdam UMC

Patients from Amsterdam UMC that underwent ECG-gated cardiac CT

Christchurch Hospital

Patients from Christchurch hospital that underwent non-ECG gated cardiac CT

John Hunter Hospital

Patients from John Hunter Hospital that underwent non-ECG gated cardiac CT

Liverpool Hospital

Patients from Liverpool Hospital that underwent ECG-gated cardiac CT

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients 18 years or older with acute ischemic stroke that underwent a cardiac CT during the acute stroke scanprotocol.

You may qualify if:

• Age 18 years or older
• Clinical diagnosis of acute ischemic stroke
• Cardiac CT acquired during acute stroke scan protocol

You may not qualify if:

• Transient ischemic attack
• Stroke mimics

Sponsors & Collaborators

• Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA): lead

Study Sites (1)

Amsterdam UMC

Amsterdam, 1105 AZ, Netherlands

Location

MeSH Terms

Conditions

Ischemic Stroke; Embolic Stroke; Thrombosis

Condition Hierarchy (Ancestors)

Stroke; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Embolism and Thrombosis

Study Officials

• Jonathan Coutinho, MD, PhD

  Amsterdam UMC

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: August 9, 2025
• First Posted: September 10, 2025
• Study Start: May 19, 2018
• Primary Completion: June 30, 2024
• Study Completion: September 1, 2025
• Last Updated: January 21, 2026

Record last verified: 2025-08

Locations

NL (1)