Dexmedetomidine Nebulization for Attenuation of Pressor Response to Laryngoscopy and Endotracheal Intubation in Sever Preeclamptic Patients
1 other identifier
interventional
100
0 countries
N/A
Brief Summary
Dexmedetomidine nebulization in sever preeclamptic patients
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Oct 2025
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 30, 2025
CompletedFirst Posted
Study publicly available on registry
September 10, 2025
CompletedStudy Start
First participant enrolled
October 15, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 15, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 15, 2026
September 10, 2025
August 1, 2025
1.1 years
August 30, 2025
September 6, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Systolic blood pressure in response to endotracheal intubation
the change in systolic blood pressure in response to endotracheal intubation
Intraoperative
Secondary Outcomes (3)
Optic nerve sheath diameter
Intraoperative
Incidence of maternal postoperative sore throat
1 hour Postoperative
Incidence of maternal postoperative hoarseness of voice
1 hour Postoperative
Study Arms (2)
Dexmedetomidine
EXPERIMENTALNebulization of dexmedetomidine
Saline
PLACEBO COMPARATORNebulization of saline
Interventions
Eligibility Criteria
You may qualify if:
- Patients with severe pre-eclampsia scheduled for cesarean section under general anesthesia
- ASA II, III
You may not qualify if:
- sever obesity (BMI ≥ 40)
- Cardiac patients
- History of diabetes mellitus
- Renal dysfunction (elevated serum creatinine \> 2mg\\dl)
- hepatic dysfunction (elevated hepatic enzyme three times above normal)
- History to hypersensitivity to the tested drug.
- Emergency surgery
- Known fetal anomalies
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Dexmedetomidine nebulization for attenuation of pressor response to laryngoscopy and endotracheal intubation in sever preeclamptic patients undergoing caesarean section under general anaesthesia. A prospective randomized clinical trial.
Study Record Dates
First Submitted
August 30, 2025
First Posted
September 10, 2025
Study Start
October 15, 2025
Primary Completion (Estimated)
November 15, 2026
Study Completion (Estimated)
December 15, 2026
Last Updated
September 10, 2025
Record last verified: 2025-08