The Risk of Adverse Pregnancy Outcomes for Long-term Exposure to Air Pollution in Pregnant Patients With Pulmonary Hypertension

NCT07164157 | Completed DMC

• 1 other identifier: 2025XMSB0000311
• Study Type: observational
• Target: 1,200
• Locations: 1 country
• Sites: 1

Brief Summary

With economic development and rapid urbanization, air pollution has become an increasingly severe public health concern. The risk of adverse pregnancy outcomes is significantly elevated for pregnant women complicated by pulmonary hypertension. However, no studies to date have specifically examined the impact of environmental factors on pulmonary hypertension in pregnant women, nor their subsequent birth outcomes. Therefore, investigating the correlation between them holds substantial clinical and public health significance.

Conditions

Pulmonary Arterial Hypertension; Air Pollution; Maternal Outcome

Keywords

pulmonary hypertension; air pollution; maternal outcome; heart failure; preterm birth; low birth weight

Outcome Measures

Primary Outcomes (1)

• 1.main maternal outcome

  including maternal death and heart failure

  diagnosis of pregnancy to six months postpartum

Secondary Outcomes (1)

• Secondary maternal outcome events

  From delivery to 42 days postpartum

Other Outcomes (1)

• 2.main offspring events

  From delivery to 42 days postpartum

Study Arms (24)

The First Affiliated Hospital of Chongqing Medical University

The Second Affiliated Hospital of Chongqing Medical University

Xiangya Hospital of Central South University

The second Xiangya Hospital of Central South University

Yan'an Hospital of Kunming City

Gansu Provincial Hospital

Qilu Hospital of Shandong University

The second hospital of Army Military University

Guizhou Provincial People's Hospital

The Second Affiliated Hospital of Nanchang University

Henan Provincial People's Hospital

Gannan Medical University

Women and Children's Hospital of Chongqing Medical University

The First People's Hosipital of Yunnan Province

People's Hosipital of Xinjiang Uygur Autonomous Region

The First Affiliated Hospital of Anhui Medical University

Yantai Yuhuangding Hospital

The Third People's Hosipital of Chengdu

Zhongda Hospital Southeast University

The First Affiliated Hospital of Xi'an Jiao Tong University

Gansu Provincial Maternity and Child-care Hospital

The First Affiliated Hospital of Guangxi Medical University

Xijing Hospital

Shenzhen People's Hospital

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Pregnant women with pulmonary hypertension(PH) who attended major medical centers included in this study from January 2013 to December 2022. Our study includes all types of pregnant women with PH, primarily those who with congenital heart disease-associated PH, followed by those with left heart disease-associated PH.

You may qualify if:

• Pregnant women with pulmonary hypertension who attended major medical centers included in this study from January 2013 to December 2022.
• Complete medical records available; ② Pulmonary artery systolic pressure ≥ 35 mmHg by echocardiography or a confirmed diagnosis of pulmonary hypertension by right heart catheterization; ③ Residential address information available at the city (district, county) level or higher.

You may not qualify if:

• ① Unclear diagnosis and completely missing address information;
• Incomplete medical records; ③ Lost to follow-up during pregnancy or within six weeks postpartum.

Sponsors & Collaborators

• Wei Huang: lead

Study Sites (1)

The First Affiliated Hospital, Chongqing Medical University

Chongqing, Chongqing Municipality, 400016, China

Location

MeSH Terms

Conditions

Pulmonary Arterial Hypertension; Hypertension, Pulmonary; Heart Failure; Premature Birth

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Hypertension; Vascular Diseases; Cardiovascular Diseases; Heart Diseases; Obstetric Labor, Premature; Obstetric Labor Complications; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: March 12, 2025
• First Posted: September 10, 2025
• Study Start: January 1, 2013
• Primary Completion: December 31, 2022
• Study Completion: December 31, 2022
• Last Updated: September 10, 2025

Record last verified: 2024-01

Locations

CN (1)