Evaluation of Systemic Inflammatory Index and Biomarkers in Relation to Inferior Alveolar Nerve Block Success and Postoperative Pain

NCT07163065 | Active Not Recruiting

• 1 other identifier: B.30.2.ATA.0.01.00/558
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate the relationship between systemic inflammatory markers and the effectiveness of inferior alveolar nerve block anesthesia in patients undergoing dental treatment. The primary focus is on the Systemic Inflammatory Index (SII) and other inflammatory biomarkers, and how they may influence both the success of anesthesia and the intensity of postoperative pain. By analyzing blood samples and clinical outcomes, the study will provide new insights into the role of systemic inflammation in anesthesia effectiveness and postoperative pain control. The findings may help clinicians predict anesthetic success and improve pain management strategies in dental practice.

Conditions

Postoperative Pain; Inferior Alveolar Nerve Block Failure; Inflammation Biomarkers; Dental Anesthesia Complications

Keywords

Systemic Inflammatory Index (SII); Neutrophil-to-Lymphocyte Ratio (NLR); Dental Anesthesia; Mandibular Block; Endodontic Pain

Outcome Measures

Primary Outcomes (1)

• Success Rate of Inferior Alveolar Nerve Block Anesthesia

  Proportion of patients achieving successful anesthesia, defined as absence of pain during dental treatment following inferior alveolar nerve block.

  Within 15 minutes after injection

Study Arms (1)

Patients Undergoing Inferior Alveolar Nerve Block

Adult patients requiring dental treatment under inferior alveolar nerve block anesthesia. Participants will undergo standard IANB anesthesia, and postoperative pain will be evaluated along with systemic inflammatory markers obtained from blood samples.

Procedure: Inferior Alveolar Nerve Block Anesthesia

Interventions

Inferior Alveolar Nerve Block Anesthesia PROCEDURE

Standard inferior alveolar nerve block anesthesia performed with lidocaine and epinephrine for mandibular dental treatment. Success rate and postoperative pain outcomes will be recorded

Patients Undergoing Inferior Alveolar Nerve Block

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients (18-65 years) requiring mandibular dental treatment under inferior alveolar nerve block anesthesia at Atatürk University Faculty of Dentistry, Department of Endodontics.

You may qualify if:

• Patients aged between 18 and 65 years.
• Patients with a pain score greater than 54 on the Heft-Parker Visual Analog Scale (VAS).
• Patients classified as ASA I according to the American Society of Anesthesiologists (ASA).
• Teeth with probing depths less than 3 mm, suitable for rubber dam placement and restoration.
• Vital mandibular molar teeth with a clinical diagnosis of irreversible pulpitis, confirmed by pulp vitality tests (electric pulp testing and cold testing).
• Presence of bleeding upon access to the pulp chamber.
• No use of non-steroidal anti-inflammatory drugs (NSAIDs) within the last 12 hours.
• Absence of allergy to articaine.
• Patient's consent to provide a blood sample.

You may not qualify if:

• Patients classified as ASA II or higher.
• Pregnant women or those with suspected pregnancy.
• Patients with periodontal pockets greater than 3 mm in the involved tooth.
• Patients who received treatment with NSAIDs within the last 12 hours.
• Patients allergic to articaine.
• Teeth that had undergone previous endodontic treatment.
• Teeth with extensive structural loss preventing rubber dam isolation.
• Presence of internal or external root resorption.

Sponsors & Collaborators

• KEZBAN MELTEM ÇOLAK: lead

Study Sites (1)

Atatürk University Faculty of Dentistry, Department of Endodontics

Erzurum, Erzurum, 25240, Turkey (Türkiye)

Location

Related Publications (2)

• Dziedzic EA, Gasior JS, Tuzimek A, Paleczny J, Junka A, Dabrowski M, Jankowski P. Investigation of the Associations of Novel Inflammatory Biomarkers-Systemic Inflammatory Index (SII) and Systemic Inflammatory Response Index (SIRI)-With the Severity of Coronary Artery Disease and Acute Coronary Syndrome Occurrence. Int J Mol Sci. 2022 Aug 23;23(17):9553. doi: 10.3390/ijms23179553.

  PMID: 36076952 BACKGROUND

• Gibson PH, Croal BL, Cuthbertson BH, Small GR, Ifezulike AI, Gibson G, Jeffrey RR, Buchan KG, El-Shafei H, Hillis GS. Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting. Am Heart J. 2007 Nov;154(5):995-1002. doi: 10.1016/j.ahj.2007.06.043.

  PMID: 17967611 BACKGROUND

Related Links

• Related Info

Biospecimen

Retention: SAMPLES WITHOUT DNA

Peripheral blood samples for hematological and inflammatory marker analysis.

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Officials

• KEZBAN MELTEM ÇOLAK

  Atatürk University, Faculty of Dentistry, Department of Endodontics

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 7 Days
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor of Endodontics, Principal Investigator

Study Record Dates

• First Submitted: September 1, 2025
• First Posted: September 9, 2025
• Study Start: September 27, 2024
• Primary Completion: November 1, 2024
• Study Completion: October 15, 2025
• Last Updated: September 9, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)