Use of Neuromuscular Electrical Stimulation to Prevent Exercise Resistance

NCT07161648 | Recruiting

• 1 other identifier: 5208
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The study will find out if 100 minutes of electrical stimulation of muscle prevents the unfavorable consequence of insufficient exercise.

Conditions

Fat Metabolism

Keywords

exercise; exercise resistance; electrical stimulation

Outcome Measures

Primary Outcomes (1)

• Fat oxidation

  Circulating triglyceride concentration after eating a high fat meal.

  Blood will be sampled and triglyceride concentration measured. Study participants will eat a meal. Blood will be sampled and triglyceride concentration measured every 30-minutes for 4 hours.

Study Arms (3)

Establishing the normal benefit of exercise

NO INTERVENTION

Study participants will complete treadmill exercise. During the same day, they will walk a minimum of 8,500 steps. The next day, fat oxidation will be measured after eating a high-fat meal.

Demonstrating exercise resistance

NO INTERVENTION

Study participants will complete treadmill exercise. They will walk no more than 5,000 steps on the same day. The next day, fat oxidation will be measured after eating a high-fat meal.

Trying to prevent exercise resistance

EXPERIMENTAL

Study participants will complete treadmill exercise. They will walk no more than 5,000 steps on the same day. They will receive 100 minutes of neuromuscular electrical stimulation. The next day, fat oxidation will be measured after eating a high-fat meal.

Other: neuromuscular electrical stimulation

Interventions

neuromuscular electrical stimulation OTHER

The study participants will engage in 100-minutes of neuromuscular electrical stimulation (NMES). NMES pads are sticky pieces of plastic, similar in size to a 25-cent coin. The pads will be placed on the bellies of thigh muscles (the vastus lateralis, vastus medialis), and calf muscles (the long and short head of the gastrocnemius). These skeletal muscles are selected due to their size (thereby promoting a bigger increase for metabolic rate compared with a small muscle), because they are relatively superficial, and because previous published studies of NMES used these anatomical locations.

Trying to prevent exercise resistance

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Regularly active (more than 30 minutes of exercise per day, 3 days per week, over the previous 12 months)
• Ability to complete at least one hour of treadmill exercise (i.e. jogging/running),
• Willing to abstain from caffeine and alcohol for 24-hours prior to three different study visits
• Competency in English

You may not qualify if:

• Current or previous injuries that may hinder a participant's ability to exercise on a treadmill
• A history of cardiopulmonary disorder that may be contra-indicative to treadmill exercise
• Current use of cardio-pulmonary medication to treat a cardio-pulmonary condition
• Currently breastfeeding
• Pregnancy

Sponsors & Collaborators

• Colorado State University: lead

Study Sites (1)

Colorado State University

Fort Collins, Colorado, 80523, United States

RECRUITING

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Christopher Bell, Ph.D.

  Colorado State University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Christopher Bell, PhD

CONTACT

970-491-7522; christopher.bell@colostate.edu

Ally Tripure, B.S.

CONTACT

9704913495; a.tripure@colostate.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Prof

Study Record Dates

• First Submitted: September 2, 2025
• First Posted: September 8, 2025
• Study Start: October 17, 2024
• Primary Completion (Estimated): September 30, 2026
• Study Completion (Estimated): September 30, 2026
• Last Updated: November 14, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)