Peripheral Nerve Activation Sensitivity

NCT07160413 | Recruiting

• 2 other identifiers: 2025-00776108.018 IP-LS
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Volunteers will undergo various peripheral nerve stimulations (electric, electromagnetic, and temporal interference) to evaluate each method's sensitivity. The main objective is to examine the relationship between nerve activation and coil placement relative to the nerve, as well as how different coil types influence maximal nerve activation.

Conditions

Nerve Excitation Sensitivity

Keywords

Peripheral nerve stimulation; Magnetic and electric stimulation; Sensitivity of nerves to magnetic fields

Outcome Measures

Primary Outcomes (1)

• Maximum nerve activation response to electromagnetic stimulation with different coils

  Maximum of the measured signals (muscle contraction from electromyography (EMG) and finger movement from accelerometer) obtained across all stimulation positions at a given stimulation intensity for each coil type. This reflects the relative sensitivity of peripheral nerves to electromagnetic stimulation with different coil designs.

  Day 1

Secondary Outcomes (3)

• Spatial range of nerve activation with electromagnetic coils

  Day 1

• Spatial range of nerve activation with neuromuscular electrical stimulation electrodes (NMES)

  Day 1

• Amplitude ratios of temporal interference stimulation (TIS) electrodes associated with nerve activation

  Day 1

Study Arms (1)

Stimulated

EXPERIMENTAL

Device: Electric and electromagnetic stimulation

Interventions

Electric and electromagnetic stimulation DEVICE

Application of electromagnetic and electric stimulation using coils of different designs and electrodes to assess peripheral nerve sensitivity. The stimulation is momentary, non-therapeutic, and performed for basic science research purposes

Stimulated

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Person aged \> 18 years
• Signed informed consent
• Healthy
• Willingness and ability to adhere to study procedures

You may not qualify if:

• Known hypersensitivity to electric or electromagnetic stimulation
• Any implanted metal or electronic device in the upper body (except dental work such as fillings or braces), e.g., active medical devices, metal implants
• Neurological or neuromuscular disorders or conditions
• History of seizures or epilepsy
• Current treatment with drugs that lower seizure threshold (e.g., certain analgesics, methylxanthines, antipsychotics, antidepressants, antiepileptics, anesthetics)
• Pregnancy or breastfeeding
• Surgical intervention of the arm within the last 4 weeks
• Allergy to adhesives or ultrasound gel components (e.g., polyethylene glycols)
• Skin lesions, infections, or strictures in the arm region
• Tattoos on the stimulated (right) arm and hand, or in any area likely to be captured in video recordings
• Inability to follow study procedures (e.g., due to language barrier, psychological disorders, dementia)
• Participant deprived of liberty by administrative or judicial decision or under legal guardianship

Sponsors & Collaborators

• Thomas Niederhauser: lead
• Bern University of Applied Sciences: collaborator
• Swiss Paraplegic Research, Nottwil: collaborator

Study Sites (1)

Institute for Human Centered Engineering HuCE

Biel, Biel, 2502, Switzerland

RECRUITING

Central Study Contacts

Thomas Niederhauser, PhD

CONTACT

+41 32 321 67 63; thomas.niederhauser@bfh.ch

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Prof. Dr.

Study Record Dates

• First Submitted: August 29, 2025
• First Posted: September 8, 2025
• Study Start: September 1, 2025
• Primary Completion: December 31, 2025
• Study Completion (Estimated): December 31, 2026
• Last Updated: September 12, 2025

Record last verified: 2025-09

Locations

CH (1)