Blood Glucose Levels After Bread Consumption Between Participants With Normal Weight and Overweight/Obesity

NCT07158762 | Completed

• 2 other identifiers: P136390Ref 71978
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Obesity and increased blood glucose peaks are risk factors for type 2 diabetes mellitus (T2DM). Few studies have explored whether increased body fat contributes to higher blood glucose peaks after food consumption. This study aimed to investigate differences in blood glucose levels between healthy adults with normal weight and those with overweight/obesity after consuming two commercially available breads (white and wholemeal) with different dietary fibre contents. In this study, 20 healthy adults (10 normal weight, 10 overweight/obese) consumed two slices of white bread (100 g, fibre 3.6 g) or wholemeal bread (88 g, fibre 5.6 g) alongside 150 ml of orange juice and 10 g of butter on separate visits in random order after fasting for 8-12 hours. Blood glucose concentration was measured while fasting (before bread consumption) and at 30, 60, 90, and 120 minutes after consumption using finger-prick tests. Information on age, gender, ethnicity, body mass index (BMI), and body fat percentage (BF%) was also collected.

Conditions

Healthy Participants; Normal Weight Adults; Overweight or Obese Adults

Keywords

postprandial glycaemic response; bread; body mass index; body fat percentage

Outcome Measures

Primary Outcomes (1)

• Postprandial glycaemic response

  Postprandial blood glucose was measured at 0 (fasting), 30, 60, 90 and 120 minutes by finger prick performed by the researcher using Biosen Blood Glucose/Lactate Analyser (EKF Diagnostics, Cardiff).

  2 hours

Study Arms (2)

Participants with normal weight

ACTIVE COMPARATOR

Healthy participants with a body mass index between 18.5-24.9 kg/m2.

Other: White bread; Other: Wholemeal bread

Participants with overweight or obesity

EXPERIMENTAL

Healthy participants with a body mass index ≥ 25 kg/m2

Other: White bread; Other: Wholemeal bread

Interventions

White bread OTHER

Two slices of white bread consumption along with 150 ml of pure orange juice and 10 g of butter

Participants with normal weight; Participants with overweight or obesity

Wholemeal bread OTHER

Two slices of wholemeal bread consumption along with 150 ml of pure orange juice and 10 g of butter

Participants with normal weight; Participants with overweight or obesity

Eligibility Criteria

• Age: 18 Years - 50 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• healthy adults of 18 - 50 years

You may not qualify if:

• participants with diabetes
• digestive system diseases
• BMI \< 18.5 kg/m2
• coeliac disease
• other chronic diseases
• blood clotting issues
• those who could not consume the study meals due to food allergies or other reasons

Sponsors & Collaborators

• City, University of London: lead
• Coventry University: collaborator

Study Sites (1)

Coventry University

Coventry, United Kingdom

Location

MeSH Terms

Conditions

Overweight

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Yizhi Xu, PhD

  Coventry University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 26, 2025
• First Posted: September 8, 2025
• Study Start: May 1, 2022
• Primary Completion: July 31, 2022
• Study Completion: July 31, 2022
• Last Updated: September 8, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)