Gingival Crevicular Fluid Oxidized Low-Density Lipoprotein Levels in Health and Stage III/IV Periodontitis

NCT07157878 | Not Yet Recruiting DMC

• 2 other identifiers: GCF+ advanced periodontitiscommittee 1166
• Study Type: observational
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

Periodontitis is a chronic, multifactorial inflammatory disease primarily caused by dysbiotic plaque biofilms, characterized by the progressive destruction of the supporting structures of the teeth. In advanced stages (Stage III/IV), periodontitis leads to significant attachment and bone loss, often culminating in tooth loss and a negative impact on the patient's quality of life. Recent evidence has emphasized the systemic implications of periodontal inflammation, suggesting a bidirectional relationship between periodontitis and various systemic conditions, especially cardiovascular diseases

Conditions

Periodontal Diseases; LDL Hyperlipoproteinemia

Keywords

Periodontitis; LDL; GCF; periodontal health

Outcome Measures

Primary Outcomes (1)

• The concentration of oxLDL in GCF

  The concentration of oxLDL in GCF, measured in pg/mL, in geriatric patients with Stage III/IV periodontitis compared to periodontally healthy geriatric individuals.

  at baseline (day1)

Study Arms (2)

control group

periodontally healthy participants

study group

periodontitis stage 3 and 4

Eligibility Criteria

• Age: 30 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

cross sectional study in upper egypt to detect the level of LDL in advanced periodontitis patient

You may qualify if:

• For all participants (applies to both groups):
• Age 30-60 years.
• Systemically healthy (based on medical history and physician clearance, if needed).
• No history of periodontal treatment within the last 6 months.

You may not qualify if:

• \. History of systemic diseases affecting periodontium (e.g., uncontrolled diabetes, autoimmune diseases, osteoporosis).
• \. Current or past diagnosis of Alzheimer's disease or other neurodegenerative disorders.
• \. Use of medications affecting periodontal status (e.g., immunosuppressants, long-term corticosteroids, anticonvulsants).
• \. Antibiotic or anti-inflammatory therapy within the past 3 months. 5. Current smokers or history of smoking in the past year.

Sponsors & Collaborators

• shaimaa hamdy: lead

Biospecimen

Retention: SAMPLES WITHOUT DNA

A gingival crevicular fluid sample was taken for LDL detection to assess the correlation between periodontitis and LDL

MeSH Terms

Conditions

Periodontal Diseases; Periodontitis

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases

Study Officials

• shaimaa Hamdy, lecturer

  lecturer of periodontology Nahda University

  STUDY CHAIR

Central Study Contacts

shaimaa Hamdy, lecturer of Periodontology

CONTACT

+201030576405; shimaa.3m.sh@gmail.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Target Duration: 2 Days
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: lecturer of periodontology

Study Record Dates

• First Submitted: August 19, 2025
• First Posted: September 5, 2025
• Study Start: September 15, 2025
• Primary Completion: September 15, 2025
• Study Completion: September 15, 2025
• Last Updated: September 5, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share