Surveillance of Respiratory Viruses in Healthcare and Animal Workers

NCT07156890 | Recruiting DMC

• 1 other identifier: NL-005629
• Study Type: observational
• Target: 250
• Locations: 1 country
• Sites: 1

Brief Summary

Outbreaks with viruses occur continuously, and novel viruses or new variants of existing viruses can surface after a zoonotic event or human-to-human transmission. This project proposal is designed to detect early circulation of (novel) respiratory viruses in both symptomatic and asymptomatic participants, either by direct detection of the virus or changes in local or systemic immunity. Additionally, SENTINEL will provide information on infectivity and (protective) immune responses in viral outbreaks or vaccination campaigns.

Conditions

Respiratory Viruses

Keywords

healthcare workers; respiratory viruses; pandemic preparedness; virus-specific immunity; surveillance; vaccines

Outcome Measures

Primary Outcomes (5)

• Main study endpoint

  Identification of circulating respiratory viruses by targeted molecular testing in symptomatic participants

  60 months

• Main study endpoint

  Identification of circulating respiratory viruses by metagenomic sequencing in symptomatic participants

  60 months

• Main study endpoint

  Identification of circulating respiratory viruses by virus culture in symptomatic participants

  60 months

• Main study endpoint

  Longitudinal monitoring of local immune responses, for example by, but not limited to, quantitative, qualitative and/or functional antibody assays (ELISA, VNT, PRNT) to detect changes as a proxy for asymptomatic exposure to respiratory viruses.

  60 months

• Main study endpoint

  Longitudinal monitoring of systemic immune responses, for example by, but not limited to, quantitative, qualitative and/or functional antibody assays (ELISA, VNT, PRNT) to detect changes as a proxy for asymptomatic exposure to respiratory viruses.

  60 months

Secondary Outcomes (5)

• Secondary study endpoint

  60 months

• Secondary study endpoint

  60 months

• Secondary study endpoint

  60 months

• Secondary study endpoint

  60 months

• Secondary study endpoint

  60 months

Study Arms (2)

Health care workers

Hospital staff with and without direct contact to patients (HCW)

Animal workers

Animal workers with direct contact to animals (AW)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Individuals working at healthcare facilities or facilities with animals (e.g. farms, bird ringers, or slaughterhouses). We will include an average of 250 participants per year, over a maximum of 5 years. 1,000 participants will be recruited in total for the study.

You may qualify if:

• years or older
• Health care workers with or without direct patient contact
• Animal workers with or without direct animal contact

You may not qualify if:

• \<18 years

Sponsors & Collaborators

• Erasmus Medical Center: lead

Study Sites (1)

ErasmusMC

Rotterdam, South Holland, 3015GD, Netherlands

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

50ml of whole blood per study visit, 1 throat swab per infection, 1 nasal fluid lining collector (nasosorption) per study visit, 1 nasal brush per study visit

Central Study Contacts

Corine H. Geurts van Kessel, Dr

CONTACT

+31643271384; c.geurtsvankessel@erasmusmc.nl

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 60 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical microbiologist

Study Record Dates

• First Submitted: August 27, 2025
• First Posted: September 5, 2025
• Study Start: August 19, 2024
• Primary Completion (Estimated): August 1, 2029
• Study Completion (Estimated): August 1, 2029
• Last Updated: September 5, 2025

Record last verified: 2025-09

Locations

NL (1)