Surface EMG Testing on Swallowing in EoE Patients

NCT07156357 | Recruiting

• 1 other identifier: 24-009832
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Evaluating swallowing food with surface electromyography (EMG) machine in patients with Eosinophilic Esophagitis

Conditions

Eosinophilic Esophagitis (EoE)

Outcome Measures

Primary Outcomes (1)

• Preparatory phase time

  Comparison of preparatory phase between cohorts

  Through study completion an average of 2 days

Secondary Outcomes (1)

• Time difference in swallow initiation

  Through study completion an average of 2 days

Study Arms (2)

Controls

Subjects who can swallow normally

Diagnostic Test: Surface Electromyography; Diagnostic Test: Fiberoptic Endoscopic Evaluation of Swallowing

Eosinophilic Esophagitis

Subjects with Eosinophilic Esophagitis

Diagnostic Test: Surface Electromyography; Diagnostic Test: Fiberoptic Endoscopic Evaluation of Swallowing

Interventions

Surface Electromyography DIAGNOSTIC_TEST

Tests performed to evaluate swallowing function

Controls; Eosinophilic Esophagitis

Fiberoptic Endoscopic Evaluation of Swallowing DIAGNOSTIC_TEST

Assessment of swallowing function

Controls; Eosinophilic Esophagitis

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

We will recruit patients with EoE seen in the esophageal clinic. Controls will be recruited by monitoring for patients that present for video swallow with speech language pathology and have a normal video swallow.

You may qualify if:

• Controls
• Normal video swallow or score of 0 for dysphagia on ESSAI questionnaire
• absence of dysphagia
• age \>18 EoE participants
• Documentation of EoE diagnosis by histologic criteria,
• \>15 eos/hpf on most recent esophageal biopsy
• age \>18

You may not qualify if:

• Abnormal baseline video swallow
• lack of MSK coordination to eat test meal
• underlying neuromuscular disorder.

Sponsors & Collaborators

• Mayo Clinic: lead

Study Sites (1)

Mayo Clinic

Rochester, Minnesota, 55905, United States

RECRUITING

MeSH Terms

Conditions

Eosinophilic Esophagitis

Interventions

Electromyography

Condition Hierarchy (Ancestors)

Esophagitis; Esophageal Diseases; Gastrointestinal Diseases; Digestive System Diseases; Gastroenteritis; Eosinophilia; Leukocyte Disorders; Hematologic Diseases; Hemic and Lymphatic Diseases; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Intervention Hierarchy (Ancestors)

Electrodiagnosis; Diagnostic Techniques and Procedures; Diagnosis; Myography

Study Officials

• Karthik Ravi, MD

  Mayo Clinic

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ryan Alexander, MD

CONTACT

507-284-4824; alexander.ryan2@mayo.edu

Mariah Robran, CCRP

CONTACT

507-266-3595; robran.mariah@mayo.edu

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: August 15, 2025
• First Posted: September 5, 2025
• Study Start: August 4, 2025
• Primary Completion (Estimated): June 1, 2026
• Study Completion (Estimated): June 1, 2027
• Last Updated: September 5, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)