12-Week Study on the Efficacy of Two Serums in Improving Skin Aging and Tone

NCT07156071 | Completed DMC

• 1 other identifier: C23005059
• Study Type: interventional
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate the anti-aging and skin tone improvement effects of two facial serums over a 12-week period. It was conducted at a single research center with a 2-week washout period followed by full-face application of the test products for 12 weeks. A total of at least 120 healthy Chinese female participants aged 18 to 45 were enrolled and divided into two treatment groups:Each group included both early aging (18-29 years) and mature aging (30-45 years) subgroups, with at least 30 participants in each subgroup.

Conditions

Facial Skin Aging and Dullness

Outcome Measures

Primary Outcomes (4)

• Change in Dermatologist-Assessed Wrinkle Attributes

  Crow's feet wrinkles, forehead wrinkles, global wrinkles, small folds on nasolabial zone and global fine lines will be evaluated by dermatologist.

  from Baseline to Week 12

• Self-assessment Questionnaire

  Participants will complete a 5-point self-assessment questionnaire at Timm, T4w, T8w, and T12w, evaluating their perception of skin softness, smoothness, plumpness, elasticity, hydration, oil control, and visible aging signs. Ratings from 4 to 5 will be used to calculate "Top 2 box" percentage.

  12 weeks

• Change in Dermatologist-Assessed Skin Texture and Quality Attributes

  Skin smoothness (visual), skin elasticity, skin softness, skin firmness, skin plumpness, cheek pores will be evaluated by dermatologist.

  from Baseline to Week 12

• Change in Dermatologist-Assessed Skin Tone Attributes

  Skin radiance, skin translucency, skin pigmentation, skin fairness, skin tone evenness and skin dullness will be evaluated by dermatologist.

  from Baseline to Week 12

Secondary Outcomes (5)

• Change in Skin Hydration Measured by Corneometer

  12 weeks

• Change in Skin Elasticity Measured by Cutometer

  12 weeks

• Change in Transepidermal Water Loss (TEWL) Measured by Vapometer

  12 weeks

• Change in Facial Image-Based Skin Parameters Using VISIA-CR

  12 weeks

• Change in Cheek Skin Surface Condition Using VisioScan VC20

  12 weeks

Study Arms (2)

Serum 1 Group

EXPERIMENTAL

Participants in this arm applied Serum 1 (Fla#897183 329) to the full face twice daily for 12 weeks. The group included both early aging (18-29 years) and mature aging (30-45 years) subgroups.

Other: Serum 1

Serum 2 Group

EXPERIMENTAL

Participants in this arm applied Serum 2 (Fla#b50198) to the full face twice daily for 12 weeks. The group included both early aging (18-29 years) and mature aging (30-45 years) subgroups.

Other: Serum 2

Interventions

Serum 1 OTHER

Applied topically on the full face in the morning and evening for 12 weeks during the treatment period. Used by participants in the Serum 1 group.

Serum 1 Group

Serum 2 OTHER

Applied topically on the full face in the morning and evening for 12 weeks during the treatment period. Used by participants in the Serum 2 group.

Serum 2 Group

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Chinese female aged 18-45 years (evenly split among Early aging \[18-29 years\] and Mature aging \[30-45 years\]).
• All skin types (dry, normal, oily, or mixed).
• Currently experiencing lack of radiance, roughness, dullness, and fine lines or wrinkles on facial skin as self-claimed.
• Early aging group (18-29 years): Must present with corresponding severity for the attributes evaluated by Dermatologist, including:
• Skin smoothness, radiance, dullness: grade between 2 and 6 (scale 0-9);
• Size of acne marks (PIH): size ≥ 2;
• Small folds on nasolabial zone: grade between 1 and 3 (Skin Aging Atlas, 0-6 scale, Page 56-57).
• Mature aging group (30-45 years): Must present with corresponding severity for the attributes evaluated by Dermatologist, including:
• Skin smoothness, radiance, dullness: grade between 4 and 6 (scale 0-9);
• Small folds on nasolabial zone: grade between 1 and 4 (Skin Aging Atlas, 0-6 scale, Page 56-57);
• Forehead wrinkles: grade ≥ 2 (Skin Aging Atlas, 0-8 scale, Page 32-33);
• Crow's feet wrinkles: grade ≥ 2 (Skin Aging Atlas, 0-6 scale, Page 40-41).
• Regular user of serum and sunscreen products.
• Did not participate in any clinical test or cosmetic product test on skin within the last 3 months.
• In general good health at the time of the study.

Sponsors & Collaborators

• ChinaNorm: lead

Study Sites (1)

Shanghai China-norm Quality Technical Service Co., Ltd., Shanghai, Shanghai 200072

Shanghai, China

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Model Details: Participants were assigned in parallel to one of two serum groups (Serum 1 or Serum 2), based on stratification by aging type (early aging or mature aging). The products were applied twice daily over 12 weeks.

Study Record Dates

• First Submitted: August 20, 2025
• First Posted: September 4, 2025
• Study Start: November 18, 2023
• Primary Completion: March 1, 2024
• Study Completion: March 22, 2024
• Last Updated: September 8, 2025

Record last verified: 2025-09

Locations

CN (1)