Effect of Red and Blue Light Irradiation on Postoperative Wound Healing in Perianal Absces

NCT07155356 | Not Yet Recruiting DMC

• 1 other identifier: AHPutianU-012
• Study Type: interventional
• Target: 222
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate whether specialized red-blue light irradiation facilitates faster postoperative recovery and reduces complication rates in patients following perianal abscess surgery. A total of 222 eligible patients were randomly allocated equally into three groups (74 per group):①Routine Care Group: Standard wound care including cleansing and dressing changes；②Red Light Therapy Group: Routine care plus red light phototherapy；③Combined Red-Blue Light Therapy Group: Routine care plus concurrent red and blue light phototherapy.Wound healing time and incidence of complications were compared to assess postoperative recovery across interventions. The primary hypothesis posits that adjunctive phototherapy-particularly combined red-blue light irradiation-will significantly enhance wound healing, reduce edema and pain, and decrease complication rates (e.g.bleeding, urinary retention) compared to routine care alone.

Conditions

Perianal Abscess

Keywords

perianal abscess; red light phototherapy; red and blue light phototherapy; wound healing

Outcome Measures

Primary Outcomes (1)

• Wound healing time

  Defined as 100% re-epithelialization assessed by blinded evaluator.

  Measurements were taken over a time frame of 24 hours postoperatively to complete epithelialisation.

Secondary Outcomes (5)

• Postoperative pain intensity

  Baseline, Day 1, 3, 5, 7, and Day 14±2

• Peripheral tissue edema（Grade 0-3）

  Day 1, 3, 5, 7, and Day 14±2

• Assessment of Granulation Tissue in Wound Bed

  Day 1, 3, 5, 7, and Day 14±2

• Length of hospital stay

  From surgery end to discharge (up to 7 days)

• Complication incidence

  Within 30 days postoperatively

Study Arms (3)

control group

NO INTERVENTION

Routine care of patients after surgery for perianal abscesses.

Red Ligh Group

EXPERIMENTAL

Postoperative care of patients with perianal abscesses using routine plus red light irradiation.

Device: Red light exposure

Combined Red-Blue Light Group

EXPERIMENTAL

Use of routine plus red and blue light in postoperative care of patients with perianal abscesses.

Device: Red-blue light exposure

Interventions

Red light exposure DEVICE

Patients in the red light group received red light therapy concurrently with standard care.

Red Ligh Group

Red-blue light exposure DEVICE

Patients in the red and blue light group received combined red and blue light therapy concurrently with standard care。

Combined Red-Blue Light Group

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Aged between 18 and 75 years;
• Clinical diagnosis of perianal abscess；
• Procedure: Radical resection with incision and drainage.

You may not qualify if:

• Concurrent anorectal disorders (hemorrhoids, anal fissure) or malignancies/infectious diseases；
• History of psychiatric disorders；
• Analgesic use within 7 days preoperatively；
• Coagulopathy or cardiac/hepatic dysfunction；
• Pregnancy or lactation；
• Contraindications to phototherapy；
• IBD-related perianal abscess.

Sponsors & Collaborators

• The Affiliated Hospital of Putian University: lead

Study Sites (1)

Affiliated Hospital of Putian University

Putian, China

Location

MeSH Terms

Conditions

Erythema

Condition Hierarchy (Ancestors)

Skin Diseases; Skin and Connective Tissue Diseases; Skin Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Chenxing C Jian

CONTACT

+8613959538950; ptyyjcx@126.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 31, 2025
• First Posted: September 4, 2025
• Study Start: September 15, 2025
• Primary Completion (Estimated): August 14, 2026
• Study Completion (Estimated): September 30, 2026
• Last Updated: September 4, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)