Impact of Covid-19 on Syphilis

NCT07150871 | Active Not Recruiting

• 1 other identifier: ASO.Minf.25.01
• Study Type: observational
• Target: 240
• Locations: 1 country
• Sites: 1

Brief Summary

Sexually transmitted infections (STIs) represent a significant challenge to global public health. Although many of these infections are treatable, failure to diagnose and delayed treatment can lead to serious complications, including infertility, chronic inflammatory diseases, and an increased risk of HIV transmission. The COVID-19 pandemic has had a significant impact on healthcare management, the economy, and citizens' lifestyles. The first lockdown in the spring of 2020 affected the entire country, while in the following months, government measures were differentiated on a regional basis, with varying restrictions on activities and mobility. Physical distancing, the use of personal protective equipment, fear of contagion, and health restrictions contributed to a delay in STI diagnoses, resulting in an increase in transmission and severity of cases diagnosed after 2022.

Conditions

Syphilis; COVID - 19; HIV (Human Immunodeficiency Virus); Retrospective Studies

Outcome Measures

Primary Outcomes (1)

• Trend of syphilis

  Analyze the trend of syphilis before and after the COVID-19 pandemic

  Baseline

Secondary Outcomes (3)

• Characteristics of affected patients

  Baseline

• Interaction between syphilis and HIV

  Baseline

• Infection Recurrence Rate

  Baseline

Interventions

Patients diagnosed with syphilis OTHER

Collection of clinical data from patients aged ≥18 years with a microbiological and/or clinical diagnosis of syphilis, treated by the Infectious Diseases Department of the University Hospital of Alessandria from 2017 to 2025.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients aged ≥18 years with a microbiological and/or clinical diagnosis of syphilis, treated by the Infectious Diseases Department of the University Hospital of Alessandria from 2017 to 2025

You may qualify if:

• Patients aged ≥18 years
• Patients with microbiological and/or clinical diagnosis of syphilis
• Patients treated by the Infectious Diseases Department of the University Hospital of Alessandria
• Signature of informed consent form

You may not qualify if:

• Patients for whom the data required for the study are not available in medical records or electronic filing systems

Sponsors & Collaborators

• Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria: lead

Study Sites (1)

Clinical Trial Center

Alessandria, Piedmont, 15121, Italy

Location

MeSH Terms

Conditions

Syphilis; COVID-19; Acquired Immunodeficiency Syndrome

Condition Hierarchy (Ancestors)

Treponemal Infections; Spirochaetales Infections; Gram-Negative Bacterial Infections; Bacterial Infections; Bacterial Infections and Mycoses; Infections; Sexually Transmitted Diseases, Bacterial; Sexually Transmitted Diseases; Communicable Diseases; Genital Diseases; Urogenital Diseases; Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; HIV Infections; Blood-Borne Infections; Sexually Transmitted Diseases, Viral; Lentivirus Infections; Retroviridae Infections; Slow Virus Diseases; Immunologic Deficiency Syndromes; Immune System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 27, 2025
• First Posted: September 2, 2025
• Study Start: May 28, 2025
• Primary Completion: June 16, 2025
• Study Completion (Estimated): May 28, 2026
• Last Updated: September 2, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

IT (1)