Healing Effect of Tea Tree Oil on Burn

NCT07149844 | Completed Early Phase 1

• 1 other identifier: 1482025
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Tea tree oil (TTO) has been recognized for its effectiveness in treating infected burns, insect bites, and promoting wound healing. This clinical study aimed to compare the impact of Tea tree oil dressings versus conventional ones in the healing process of second degree burns wounds.

Conditions

Burn

Keywords

Burn; Tea Tree Oil

Outcome Measures

Primary Outcomes (2)

• morphological wound changes

  assessment of: wound bed, wound margin: color, size, depth, presence of exudates: its amount, color, odor, and type, or scare, edema and granulation tissue formation; in addition to assessment of the wound's surrounding skin condition for: erythema, hotness, tenderness, swelling, separation of deep tissues, fever and peri-wound skin laceration. Each item was rated to score on 2 points Likert scale: 0 = not present and 1= Present. A total score of every patient in both groups was summed up and converted into percent score. to desribe wound healing process as ; complete healing: ; Partial healing: and No healing: where higher percent represent better healing

  3 weeks

• Local infection scoring system

  Local infection scoring system was recorded as: 0= Absence of infection. 1= Presence of local signs of wound infection (redness, hotness, tenderness, purulent discharge and swelling)2 = Presence of systemic wound infection signs (fever, elevated WBCs, ESR and elevated CRP)

  3 weeks

Study Arms (1)

conventional dressing

OTHER

Conventional dressing: Is the routine study hospital's burn dressing technique, utilizing sterile topical gauze dressing that is impregnated with or laid over a topical antibacterial, silver sulphadiazin dressing secured with adhesive tape.

Drug: tea tree oil ointment

Interventions

tea tree oil ointment DRUG

Petrolatum (petroleum jelly) was sterilized in the oven at 160°C for 90 min, then The ointment was prepared as 10% .

Also known as: فtea tree ointment

conventional dressing

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Patient willing to participate and communicate
• Newly admitted with recent 2nd-degree burns (superficial or deep) involving ≤10% of TBSA
• Length of hospital stay of 10 days

You may not qualify if:

• Any associated illnesses that may affect wound healing, such as:
• Diabetes mellitus (DM)
• Immune disorders
• Pre-existing skin conditions (e.g., eczema)

Sponsors & Collaborators

• Alexandria University: lead

Study Sites (1)

Ras Eltin Hospital

Alexandria, Egypt

Location

MeSH Terms

Conditions

Burns

Condition Hierarchy (Ancestors)

Wounds and Injuries

Study Officials

• hoda fathy, prof

  Alexandria University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: early phase 1
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 18, 2025
• First Posted: September 2, 2025
• Study Start: July 2, 2021
• Primary Completion: July 22, 2023
• Study Completion: September 22, 2023
• Last Updated: September 12, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP
• Time Frame: upon acceptance of the manuscript
• Access Criteria: upon request

Locations

EG (1)