Surgery Benefits Takayasu Arteritis With Stenosis in the Descending Aorta

NCT07149805 | Completed DMC

• 3 other identifiers: 2022-PUMCH-A-191BJZQ2024001UBJ06532
• Study Type: observational
• Target: 78
• Locations: 0 countries
• Sites: N/A

Brief Summary

The long-term prognosis and optimal management for Takayasu arteritis(TA) patients with severe stenosis of the descending thoracic and abdominal aorta remain undefined. We want to compare the clinical outcomes of surgical intervention and medical management.

Conditions

Takayasu Arteritis

Outcome Measures

Primary Outcomes (2)

• all-cause mortality rate

  Patients underwent follow-up from discharge until study termination (3 years to 11 years) or death, whichever came first

• all-cause mortality rate

  Patients underwent follow-up from discharge (3 years to 11 years) until study termination or death, whichever came first

Study Arms (2)

surgerical group

Patients who underwent surgical treatment

Procedure: open surgery or interventional treatment

conservative group

Patients who underwent conservative treatment

Interventions

open surgery or interventional treatment PROCEDURE

open surgery or interventional treatment

surgerical group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

inpatients at Peking Union Medical College Hospital

You may qualify if:

• fulfilling the 1990 American College of Rheumatology criteria for the diagnosis of TA;
• having at least one site with severe narrowing in the descending thoracic and abdominal aorta;
• having symptoms caused by TA-related stenosis, such as uncontrolled hypertension, heart failure, renal ischemia, dizziness, visual disturbances, and claudication

You may not qualify if:

• Patients with arterial stenosis due to other reasons (such as typical atherosclerosis, congenital coarctation of the aorta, and anatomical abnormality) were excluded

Sponsors & Collaborators

• Peking Union Medical College Hospital: lead

MeSH Terms

Conditions

Takayasu Arteritis

Condition Hierarchy (Ancestors)

Aortic Arch Syndromes; Aortic Diseases; Vascular Diseases; Cardiovascular Diseases; Arteritis; Vasculitis; Skin Diseases, Vascular; Skin Diseases; Skin and Connective Tissue Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: July 18, 2025
• First Posted: September 2, 2025
• Study Start: January 1, 2004
• Primary Completion: January 1, 2025
• Study Completion: January 1, 2025
• Last Updated: September 2, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will share